1. A novel microRNA-based signature predicts prognosis among nasopharyngeal cancer patients.
- Author
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Wang T, Wu J, Wu Y, Cheng Y, Deng Y, Liao J, Liu H, and Peng H
- Subjects
- Area Under Curve, Humans, Kaplan-Meier Estimate, MicroRNAs metabolism, Nasopharyngeal Neoplasms pathology, Prognosis, Reproducibility of Results, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, MicroRNAs genetics, Nasopharyngeal Neoplasms genetics
- Abstract
Impact Statement: Nasopharyngeal cancer is one of the most common malignant tumors in the head and neck. Identification of promising miRNA biomarkers might benefit a lot to the detection of nasopharyngeal carcinoma. A three-miRNA signature (has-miR-142-3p, has-miR-29c, and has-miR-30e) was obviously associated with the overall survival of nasopharyngeal carcinoma patients. The model has better clinical independence and has better clinical prediction effect when combined with clinical characteristics. Our results revealed that a three-miRNA signature was a potential novel prognostic biomarker for nasopharyngeal carcinoma.
- Published
- 2021
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