1. Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk
- Author
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María Marhuenda-Muñoz, Inés Domínguez-López, Klaus Langohr, Anna Tresserra-Rimbau, Miguel Ángel Martínez González, Jordi Salas-Salvadó, Dolores Corella, María Dolores Zomeño, J. Alfredo Martínez, Angel M. Alonso-Gómez, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López-Miranda, Ramón Estruch, Francisco J. Tinahones, José Lapetra, Ll. Serra-Majem, Aurora Bueno-Cavanillas, Josep A. Tur, Vicente Martín-Sánchez, Xavier Pintó, Miguel Delgado-Rodríguez, Pilar Matía-Martín, Josep Vidal, Clotilde Vázquez, Lidia Daimiel, Emilio Ros, Estefanía Toledo, María Fernández de la Puente Cervera, Rocío Barragán, Montse Fitó, Lucas Tojal-Sierra, Enrique Gómez-Gracia, Juan Manuel Zazo, Marga Morey, Antonio García-Ríos, Rosa Casas, Ana M. Gómez-Pérez, José Manuel Santos-Lozano, Zenaida Vázquez-Ruiz, Alessandro Atzeni, Eva M. Asensio, M. Mar Gili-Riu, Vanessa Bullon, Anai Moreno-Rodriguez, Oscar Lecea, Nancy Babio, Francesca Peñas Lopez, Guadalupe Gómez Melis, Rosa M. Lamuela-Raventós, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, Generalitat de Catalunya, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), European Research Council, Junta de Andalucía, Generalitat Valenciana, Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, and Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica
- Subjects
Nutrition and Dietetics ,Mass spectrometry ,Malalties cardiovasculars ,Endocrinology, Diabetes and Metabolism ,Carotenoides ,Liquid chromatography ,Matemàtiques i estadística [Àrees temàtiques de la UPC] ,cardiovascular health ,Plasma sanguini ,Blood plasma ,Cromatografia de líquids ,Carotenoids ,Cardiovascular health ,90 Operations research, mathematical programming [Classificació AMS] ,Espectrometria de masses ,Cardiovascular diseases ,Mediterranean cooking ,plasma carotenoids ,Mediterranean diet ,Cuina mediterrània ,PREDIMED-plus study ,Food Science ,Plasma carotenoids - Abstract
Carotenoid intake has been reported to be associated with improved cardiovascular health, but there is little information on actual plasma concentrations of these compounds as biomarkers of cardiometabolic risk. The objective was to investigate the association between circulating plasma carotenoids and different cardiometabolic risk factors and the plasma fatty acid profile. This is a cross-sectional evaluation of baseline data conducted in a subcohort (106 women and 124 men) of an ongoing multi-factorial lifestyle trial for primary cardiovascular prevention. Plasma concentrations of carotenoids were quantified by liquid chromatography coupled to mass spectrometry. The associations between carotenoid concentrations and cardiometabolic risk factors were assessed using regression models adapted for interval-censored variables. Carotenoid concentrations were cross-sectionally inversely associated with serum triglyceride concentrations [-2.79 mg/dl (95% CI: -4.25, -1.34) and -5.15 mg/dl (95% CI: -7.38, -2.93), p-values = 0.0002 and, (AGL2016-75329-R and PID2020- 114022RB-I0) Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades, (AEI/FEDER 10.13039/501100011033, UE), Generalitat de Catalunya (GC) (2017SGR196, 2017SGR622), PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158, European Research Council (Advanced Research Grant 2014–2019; agreement #340918), Recercaixa (number 2013ACUP00194), Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, PI0137/2018), PROMETEO/2017/017 grant from the Generalitat Valenciana, SEMERGEN grant, ICREA, FPU17/00513
- Published
- 2022