1. Tick-pathogen interactions and vector competence: Identification of molecular drivers for tick-borne diseases
- Author
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Anna Papa, Nataliia Rudenko, Ryan O. M. Rego, Santo Caracappa, Nicholas Johnson, Marie Vancová, Ana Domingos, Alejandro Cabezas-Cruz, Christian Gortázar, Libor Grubhoffer, Maryna Golovchenko, Sarah Bonnet, Ard M. Nijhof, José de la Fuente, Katherine M. Kocan, Nieves Ayllón, Pilar Alberdi, Anthony R. Fooks, Sandra Antunes, Agustín Estrada-Peña, Karen L. Mansfield, Margarita Villar, Alessandra Torina, Ministerio de Economía y Competitividad (España), European Commission, Universidad de Castilla La Mancha, Fundação para a Ciência e a Tecnologia (Portugal), Instituto de Investigación en Recursos Cinegéticos (IREC), Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University [Stillwater] (OSU), Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), Biologie moléculaire et immunologie parasitaires et fongiques (BIPAR), École nationale vétérinaire - Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)-Laboratoire de santé animale, sites de Maisons-Alfort et de Dozulé, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Biology Centre, Institute of Parasitology, Czech Academy of Sciences [Prague] (CAS), Faculty of ScienceˇCeské Budeˇ jovice, Czechia, University of South Bohemia, Facultad de ciencias veterinarias [Sante Fe] (FCV), Universidad Nacional del Litoral [Santa Fe] (UNL), Animal and Plant Health Agency [Addlestone, UK] (APHA), Faculty of Health and Medicine, University of Surrey (UNIS), Institute of Infection and Global Health Liverpool, University of Liverpool, Institute for Parasitology and Tropical Veterinary Medicine, Freie Universität Berlin, Department of Microbiology, Medical School, University of Thessaly [Volos] (UTH), National Center of Reference for Anaplasma, Babesia, Rickettsia and Theileria, Istituto Zooprofilattico Sperimentale della Sicilia, Ministerio de Economia y Competitividad (Spain) [BFU2016-79892-P], FCT [UID/Multi/04413/2013], University of Castilla-La Mancha (UCLM), Spain, European Project: 278976, Rego, Ryan O. M., Oklahoma State University [Stillwater], Laboratoire de santé animale, sites de Maisons-Alfort et de Dozulé, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Institut National de la Recherche Agronomique (INRA)-École nationale vétérinaire d'Alfort (ENVA)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), École nationale vétérinaire - Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)-Laboratoire de santé animale, sites de Maisons-Alfort et de Normandie, Universidade Nova de Lisboa (NOVA), Czech Academy of Sciences [Prague] (ASCR), and Animal and Plant Health Agency (APHA)
- Subjects
0301 basic medicine ,Microbiology (medical) ,Anaplasma ,[SDV]Life Sciences [q-bio] ,030231 tropical medicine ,Immunology ,Babesia ,Review ,Tick ,Microbiology ,03 medical and health sciences ,0302 clinical medicine ,Ticks ,parasitic diseases ,medicine ,Disease Transmission, Infectious ,Animals ,Humans ,Microbiome ,Pathogen ,Genetics ,Tick-borne disease ,biology ,Transmission (medicine) ,Borrelia ,Flavivirus ,tick ,flavivirus ,immunology ,vaccine ,medicine.disease ,biology.organism_classification ,bacterial infections and mycoses ,Virology ,3. Good health ,030104 developmental biology ,Infectious Diseases ,Tick-Borne Diseases ,Vector (epidemiology) ,Host-Pathogen Interactions ,Identification (biology) ,Arachnid Vectors ,Vaccine - Abstract
Ticks and the pathogens they transmit constitute a growing burden for human and animal health worldwide. Vector competence is a component of vectorial capacity and depends on genetic determinants affecting the ability of a vector to transmit a pathogen. These determinants affect traits such as tick-host-pathogen and susceptibility to pathogen infection. Therefore, the elucidation of the mechanisms involved in tick-pathogen interactions that affect vector competence is essential for the identification of molecular drivers for tick-borne diseases. In this review, we provide a comprehensive overview of tick-pathogen molecular interactions for bacteria, viruses, and protozoa affecting human and animal health. Additionally, the impact of tick microbiome on these interactions was considered. Results show that different pathogens evolved similar strategies such as manipulation of the immune response to infect vectors and facilitate multiplication and transmission. Furthermore, some of these strategies may be used by pathogens to infect both tick and mammalian hosts. Identification of interactions that promote tick survival, spread, and pathogen transmission provides the opportunity to disrupt these interactions and lead to a reduction in tick burden and the prevalence of tick-borne diseases. Targeting some of the similar mechanisms used by the pathogens for infection and transmission by ticks may assist in development of preventative strategies against multiple tick-borne diseases., Part of the research included in this review was supported by the Ministerio de Economia y Competitividad (Spain) grant BFU2016-79892-P and the European Union (EU) Seventh Framework Programme (FP7) ANTIGONE project number 278976. SA and AD would like to acknowledge FCT for funds to GHTM - UID/Multi/04413/2013. MV was supported by the Research Plan of the University of Castilla-La Mancha (UCLM), Spain.
- Published
- 2017