1. Longitudinal association of dietary acid load with kidney function decline in an older adult population with metabolic syndrome
- Author
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Cristina Valle-Hita, Nerea Becerra-Tomás, Andrés Díaz-López, Zenaida Vázquez-Ruiz, Isabel Megías, Dolores Corella, Albert Goday, J. Alfredo Martínez, Ángel M. Alonso-Gómez, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López-Miranda, Ramon Estruch, Francisco J. Tinahones, José Lapetra, Lluís Serra-Majem, Aurora Bueno-Cavanillas, Josep A. Tur, Vicente Martín-Sánchez, Xavier Pintó, José J. Gaforio, Pilar Matía-Martín, Josep Vidal, Angela Amengual-Galbarte, Lidia Daimiel, Emilio Ros, Ana García-Arellano, Rocío Barragán, Montse Fitó, Patricia J. Peña-Orihuela, Alberto Asencio-Aznar, Enrique Gómez-Gracia, Diego Martinez-Urbistondo, Marga Morey, Rosa Casas, Eva María Garrido-Garrido, Lucas Tojal-Sierra, Miguel Damas-Fuentes, Estibaliz Goñi, Carolina Ortega-Azorín, Olga Castañer, Antonio Garcia-Rios, Cristina Gisbert-Sellés, Carmen Sayón-Orea, Helmut Schröder, Jordi Salas-Salvadó, and Nancy Babio
- Subjects
Síndrome metabòlica ,renal nutrition ,Endocrinology, Diabetes and Metabolism ,Chronic kidney disease (CKD) ,chronic kidney disease (CKD) ,Net endogenous acid production (NEAP) ,albuminuria ,Kidney function ,Glomerular filtration rate (GFR) ,dietary acid load ,Albuminuria ,kidney function ,Renal nutrition ,Nutrició ,Nutrition ,potential renal acid load (PRAL) ,Kidney diseases ,Nutrition and Dietetics ,net endogenous acid production (NEAP) ,Metabolic syndrome ,Dietary acid load ,Potential renal acid load (PRAL) ,Malalties del ronyó ,1111 Nutrition and Dietetics ,glomerular filtration rate (GFR) ,1001 Agricultural Biotechnology ,Food Science - Abstract
Background: Diets high in acid load may contribute to kidney function impairment. This study aimed to investigate the association between dietary acid load and 1-year changes in glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (UACR). Methods: Older adults with overweight/obesity and metabolic syndrome (mean age 65 ± 5 years, 48% women) fromthe PREDIMED-Plus study who had available data on eGFR (n = 5,874) or UACR (n = 3,639) at baseline and after 1 year of follow-up were included in this prospective analysis. Dietary acid load was estimated as potential renal acid load (PRAL) and net endogenous acid production (NEAP) at baseline froma food frequency questionnaire. Linear and logistic regression models were fitted to evaluate the associations between baseline tertiles of dietary acid load and kidney function outcomes. One year- changes in eGFR and UACR were set as the primary outcomes.We secondarily assessed 10% eGFR decline or 10% UACR increase. Results: After multiple adjustments, individuals in the highest tertile of PRAL or NEAP showed higher one-year changes in eGFR (PRAL, b: – 0.64 ml/min/1.73 m2; 95% CI: –1.21 to –0.08 and NEAP, b: –0.56 ml/min/1.73 m2; 95% CI: –1.13 to 0.01) compared to those in the lowest category. No associations with changes in UACR were found. Participants with higher levels of PRAL and NEAP had significantly higher odds of developing 10% eGFR decline (PRAL, OR: 1.28; 95% CI: 1.07–1.54 and NEAP, OR: 1.24; 95% CI: 1.03–1.50) and 10 % UACR increase (PRAL, OR: 1.23; 95% CI: 1.04–1.46) compared to individuals with lower dietary acid load. Conclusions: Higher PRAL and NEAP were associated with worse kidney function after 1 year of follow-up as measured by eGFR and UACR markers in an older Spanish population with overweight/obesity andmetabolic syndrome., CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigacion para la Salud (FIS), European Commission PI13/00673 PI13/00492 PI13/00272 PI13/01123 PI13/00462 PI13/00233 PI13/02184 PI13/00728 PI13/01090 PI13/01056 PI14/01722 PI14/00636 PI14/00618 PI14/00696 PI14/01206 PI14/01919 PI14/00853 PI14/01374 PI14/00972 PI14/00728 PI14/01471, Especial Action Project, European Research Council (ERC) European Commission 340918, La Caixa Foundation 2013ACUP00194, Junta de Andalucia PI0458/2013 PS0358/2016 PI0137/2018, Center for Forestry Research & Experimentation (CIEF), European Commission PROMETEO/2017/017 PROMETEO/2021/021 AICO/2021/347 2022 FI_B100108, SEMERGEN grant, Boosting young talent call grant program for the development of IISPV research projects 2019-2021 2019/IISPV/03, Societat Catalana d'Endocrinologia i Nutricio (SCEN) Clinical-Research Grant 2019, CIBEROBN, ICREA under the ICREA Academia programme, Generalitat de Catalunya 2022 FI_B100108, European Commission PI16/01522 PI16/01120 PI17/00764 PI17/01183 PI17/00855 PI17/01347 PI17/00525 PI17/01827 PI17/00532 PI17/00215 PI17/01441 PI17/00508 PI17/01732 PI17/00926 PI19/00957 PI19/00386 PI19/00309 PI19/01032 PI19/00576 PI19/00017 PI19/01226 PI19/00781 PI13/00233 PI13/02184 PI13/00728 PI13/01090 PI13/01056 PI14/01722 PI14/00636 PI14/00618 PI14/00696 PI14/01206 PI14/01919 PI14/00853 PI19/01560 PI19/01332 PI20/01802 PI20/00138 PI20/01532 PI20/00456 PI20/00339 PI20/00557 PI20/00886 PI20/01158 PI14/01374 PI14/00972 PI14/00728 PI14/01471 PI16/00473 PI16/00662 PI16/01873 PI16/01094 PI16/00501 PI16/00533 PI16/00381 PI16/00366
- Published
- 2022