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Additional file 2: Table S1. Clinicopathological characteristics of the patients in the training and validation cohorts stratified according to the ICS. Table S2. Immune checkpoint co-expression by tumour cells (TCs) in the training cohort. Table S3. Five-year OS, DFS and DMFS estimates for different groups. Table S4. Number of events for different groups. Table S5. Univariate analysis of factors associated with overall survival in the training and validation cohorts. Table S6. Univariate analysis of factors associated with disease-free survival in the training and validation cohorts. Table S7. Univariate analysis of factors associated with distant metastasis-free survival in the training and validation cohorts. Table S8. Multivariable Cox regression analysis of factors associated with survival in the training and validation cohorts. Table S9. Summary of the multivariable analyses of prognostic factors for OS, DFS, DMFS and corresponding risk score in the training set of 208 nasopharyngeal carcinoma patients.

Additional file 1: Figure S1. Representative images of immune checkpoint expression in TCs and TAICs from nasopharyngeal carcinoma determined by immunohistochemistry. Figure S2. Kaplan-Meier curves for disease-free survival according to 13 immune checkpoint features. Figure S3. Kaplan-Meier curves for distant metastasis-free survival according to 13 immune checkpoint features. Figure S4. Construction of the ICS, a classifier comprising 5 immune checkpoint features. Figure S5. Determination of the optimum cutoff value for the ICS risk score.