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Stepping sequence analysis. A Weight curves of NMO-rats and Control-rats during motor behavior analyses. B Deviation from the linear trajectory initially chosen by the rat once it entered the corridor was computed and scored, using the left forepaw prints.

Characterization of IgGAQP4+ used for rat brain infusion. A IgGAQP4+ binding (green) on spinal cord and optic nerve from naïve rat (longitudinal sections, immunofluorescence, IgGAQP4+ 2 as example): co-localization with GFAP (red) and AQP4 (red) on astrocyte processes. Scale bar = 20 μm. B, C Reduction of AQP4 in total cell lysate (B) and membrane preparation (C) of cultured astrocytes following 24 h contact with IgGAQP4+; IgGControl had no similar effect (Western blot, actin as control for protein deposition).

Characterization of IgGAQP4+ used for rat brain infusion. A IgGAQP4+ binding (green) on spinal cord and optic nerve from naïve rat (longitudinal sections, immunofluorescence, IgGAQP4+ 2 as example): co-localization with GFAP (red) and AQP4 (red) on astrocyte processes. Scale bar = 20 μm. B, C Reduction of AQP4 in total cell lysate (B) and membrane preparation (C) of cultured astrocytes following 24 h contact with IgGAQP4+; IgGControl had no similar effect (Western blot, actin as control for protein deposition).

Low immune cell infiltration in NMO-rat. CD45+ lymphocytes infiltrated in the brain, optic nerve, and spinal cord of NMO-rat and Control-rat at low level (D7). Scale bar = 20 μm.

Stepping sequence analysis. A Weight curves of NMO-rats and Control-rats during motor behavior analyses. B Deviation from the linear trajectory initially chosen by the rat once it entered the corridor was computed and scored, using the left forepaw prints.

Low immune cell infiltration in NMO-rat. CD45+ lymphocytes infiltrated in the brain, optic nerve, and spinal cord of NMO-rat and Control-rat at low level (D7). Scale bar = 20 μm.