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Additional file 1: Table S1. AHRR and F2LR3 CpG sites and their association with smoking and PM2.5. Table S2. Multiple linear regression analysis showing the association of smoking and PM2.5 with F2RL3 cg03636183 methylation in the study participants. Table S3. Multiple linear regression analysis showing the association of smoking and PM2.5 with F2RL3 cg03636183 methylation in the study participants stratified by sex. Table S4. Multiple linear regression analysis showing the association of smoking and living in PM2.5 areas with F2RL3 cg03636183 methylation in the study participants. Table S5. Multiple linear regression analysis showing the association of smoking and living in PM2.5 areas and F2RL3 cg03636183 methylation in the study participants stratified by sex.

Spearman correlation between PM2.5 concentrations (Îźg/m3) and mean methylation levels (beta values) in the northern, north-central, central, and southern areas. The methylation beta values decrease as PM2.5 levels increase. (DOCX 40 kb)

Table S1. Multiple linear regression showing beta coefficients of SOX2 methylation both in and outside the promoter region. Table S2. Multiple linear regression showing beta coefficients of SOX2 methylation in the exon. Table S3. Multiple linear regression showing beta coefficients of SOX2 methylation in the 3UTR region. Table S4. Multiple linear regression showing beta coefficients of KRAS promoter methylation. (DOCX 22 kb)

AHRR CpG sites significantly associated with PM2.5. (DOCX 20 kb)