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Additional file 3: Table S1. Demographics and disease characteristics II, all variables were analysed per breast, IBLR In-breast local recurrence, NP New primary tumor, DF-Cohort Disease free cohort, D-cohort Disease cohort, IQR interquartile range.

Additional file 2: Figure S2. RFGT. Example of a measurement of residual fibroglandular tissue (RFGT) after nipple sparing mastectomy and reconstruction with an implant. RFGT was identified and measured in the retroareolar region and in the lateral part of the breast.

Additional file 1: Figure S1. FGT volume. Example of a segmentation performed in a right breast before mastectomy with the software ITK-SNAP. A threshold was defined to select the intensity of fibroglandular tissue (FGT) and multiple regions of interest were position in order to segment the whole area of FGT. The segmentation of the volume was performed automatically and the final volume was revised by the reader (board certified breast radiologist). The final measured volume is shown in red.

Additional file 4: Table S2. Reconstruction data, all variables were analysed per breast, IBLR In-breast local recurrence, NP New primary tumor, DF-cohort Disease free cohort, D-cohort Disease cohort.