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Additional file 9: Network S2. CellDesigner diagram as pdf.

Additional file 2: Figure S1. Coverage of the Ras network with directed vs undirected interactions. Figure S2.. Network centrality analysis for hub and non-hub proteins. Figure S3. Crosstalk of the Ras-effector downstream proteins across the 12 effector classes. Figure S4. Shared proteins among the 12 effector classes. Figure S5. Subcellular localization and interaction compatibility. Figure S6. PANTHER GO pathways analysis of the 12 effector classes. Figure S7. Differential enrichment of the SysGO Processes (1) by effector class. Figure S8. Comparison of the enriched class-specific processes with literature reports.

Additional file 3: Supplementary Figures.

Additional file 2: Supplementary Note.

Figure S1. Analysis of the historical biogeography of E. verrucosa based on a total dataset of 143 sequences (excluding the GenBank sequences). (DOCX 304 kb)

Table S4. Analysis of pairwise genetic differentiation in a total dataset of 143 specimens of Eriphia verrucosa (excluding the twelve sequences from GenBank). (DOCX 17 kb)

Table S2. Pattern of assignment of the twelve Cox1 sequences of Eriphia verrucosa (retrieved from GenBank) to the detected haplotypes in this study. (DOCX 11 kb)

Table S3. Geographic distribution of the 30 haplotypes of E. verrucosa recorded at the 15 defined populations within the East Atlantic Ocean and Mediterranean Sea. (DOCX 16 kb)

Table S1. Estimation of genetic diversity parameters in Atlantic and Mediterranean specimens of Eriphia verrucosa, based on two analyzed datasets (including and excluding retrieved sequences from GenBank). (DOCX 13 kb)