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Additional file 1:. S-1. Model details. S-2. Model calibration. S-3. Modeling the effects of the one-time intervention. S-4. Modeling the effects of medium-term health system strengthening. S-5. Sensitivity analyses. Figure S-1. Comparison of model simulations, and calibration targets. Figure S-2. Sensitivity analyses of the secondary outcome, TB cases averted over 10 years by a combined intervention of a one-time campaign plus health system strengthening. Figure S-3. Comparing the impact of curing LTBI versus TB disease. Figure S-4. The impact of a one-time intervention (without health system strengthening) when the intervention was targeted to the high-risk population. Figure S-5. The impact of a one-time intervention (without health system strengthening), with shorter duration of early LTBI. Figure S-6. The impact of the full intervention when preventive therapy is limited to recent infections. Table S-1. Model parameters. Table S-2. Model parameters for one-time intervention.

Additional file 1: Supplemental methods, Tables S1-S6, and Figures S1-S5. Supplemental methods ��� Additional details of primary human subjects data collection, estimation of model parameters, state-transition model, and approach to probabilistic parameter sampling. Table S1. Parameter estimates, sizes of latent and subclinical progressor populations. Table S2. Parameter estimates, preventive therapy efficacy and related parameters. Table S3. Parameter estimates, preventive therapy resistance acquisition. Table S4. Parameter estimates, TB treatment outcomes. Table S5. Composition of cohorts with respect to initial drug resistance and age or CD4 count. Table S6. Correspondence between baseline culture-positive TB prevalence and 3-month clinical TB incidence in cohort of people with newly diagnosed HIV and a negative TB symptom screen in Kwa-Zulu Natal. Fig S1. ��� Projected outcomes of 4R or 6H, each compared to no TPT, among a cohort of 1000 all-age Household contacts. Fig S2. Head-to-head comparison of TB outcomes after TPT, comparing 4R regimen to 6H. Fig S3. Effect of reduced access on the impact of subclinical TB screening prior to TPT, among HHC cohort. Fig S4. Sensitivity of key results to individual parameters. Fig S5 ��� Projected outcomes of 4R or 6H, each compared to no TPT, among 1000 household contacts, when TPT is only considered for the 17% of contacts who are under age 5

Additional file 1. Supplemental Results.

Detailed methodology for cost analyses, simulation model development, and sensitivity analyses. (DOCX 2.10 mb)

Additional file 1: Text S1. Expert consultation.

Supplemental Material. Contains supplementary methods including a complete description of the model, and supplementary results tables and figures. (DOCX 234 kb)

Additional file 2: Text S2. Model equations.

Additional file 4: Table S1. Summary of cost per death or infectious person-day averted of results presented in the main text.

Additional file 2: Text S2. Model equations.

Additional file 4: Table S1. Summary of cost per death or infectious person-day averted of results presented in the main text.

Additional file 1: Text S1. Expert consultation.