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Logistic regression (“enter” method) in patients with septic shock (n = 478) in differing demographic variables, missing data imputed. Number (N) of imputed values and percentages of the cohort are given. Results of logistic regression in patients with septic shock showing that BMI, use of NSAID as daily medication, arteriosclerosis, COPD, administration of contrast medium prior to ICU admission, administration of colloids prior to ICU admission, SAPS II without age or renal components, operative admission, and source of infection were significantly associated with KDIGO stage 2–3 AKI. (DOC 53 kb)

Association between acute kidney injury and the studied polymorphisms, recessive and dominant genetic models. Association between acute kidney injury and the polymorphisms studied in septic patients, patients with septic shock and all genotyped patients, recessive and dominant genetic models. Univariate and multivariate associations are reported. In dominant genetic model in patients with septic shock the SNPs rs2093266 and rs1955656 were significantly associated with KDIGO stage 2â 3 AKI after adjustment. (DOC 89 kb)

Association between acute kidney injury and the polymorphisms studied in all genotyped patients (nâ =â 2146) (additive genetic model). Association between acute kidney injury and the studied polymorphisms in all genotyped patients was tested in univariate and multivariate models. No significant associations are reported. (DOC 35 kb)

Detailed power calculations for each SNP, for power to report the additionional risk given known minor allele frequencies and risk ratios. (DOC 22 kb)

Logistic regression (“enter” method) in all genotyped patients (n = 2146) in differing demographic variables, missing data imputed. Number (N) of imputed values and the percentages of the cohort are given. Logistic regression in all genotyped patients showed that BMI, chronic liver disease, use of NSAID as daily medication, use of warfarin as daily medication, administration of contrast medium prior to ICU admission, administration of colloids prior to ICU admission, administration of albumin prior to ICU admission, maximum white blood cell count, minimum platelet count, SAPS II without age or renal components, operative admission, and source of infection were significantly associated with KDIGO stage 2–3 AKI. (DOC 72 kb)

Logistic regression (the “enter” method) in patients with sepsis (n = 653) in differing demographic variables, missing data imputed. Number (N) of imputed values and percentages of the cohort are given. Results of logistic regression in patients with sepsis showing that higher BMI, not having COPD, use of NSAID as daily medication, administration of contrast medium prior to ICU admission, SAPS II score without renal or age components, and source of infection were significantly associated with KDIGO stage 2–3 AKI. (DOC 54 kb)

Logistic regression (the “enter” method) in patients with sepsis (n = 653) in differing demographic variables, missing data imputed. Number (N) of imputed values and percentages of the cohort are given. Results of logistic regression in patients with sepsis showing that higher BMI, not having COPD, use of NSAID as daily medication, administration of contrast medium prior to ICU admission, SAPS II score without renal or age components, and source of infection were significantly associated with KDIGO stage 2–3 AKI. (DOC 54 kb)

Detailed power calculations for each SNP, for power to report the additionional risk given known minor allele frequencies and risk ratios. (DOC 22 kb)

Association between acute kidney injury and the studied polymorphisms, recessive and dominant genetic models. Association between acute kidney injury and the polymorphisms studied in septic patients, patients with septic shock and all genotyped patients, recessive and dominant genetic models. Univariate and multivariate associations are reported. In dominant genetic model in patients with septic shock the SNPs rs2093266 and rs1955656 were significantly associated with KDIGO stage 2â 3 AKI after adjustment. (DOC 89 kb)

Primer sequences. Polymerase chain reaction (PCR) 1 and 2 and extension primer sequences. (DOC 30 kb)

FINNAKI study enrollment and inclusion of patients. Report of the enrollment period and inclusion and exclusion criteria. (DOC 22 kb)

Primer sequences. Polymerase chain reaction (PCR) 1 and 2 and extension primer sequences. (DOC 30 kb)

Logistic regression (“enter” method) in all genotyped patients (n = 2146) in differing demographic variables, missing data imputed. Number (N) of imputed values and the percentages of the cohort are given. Logistic regression in all genotyped patients showed that BMI, chronic liver disease, use of NSAID as daily medication, use of warfarin as daily medication, administration of contrast medium prior to ICU admission, administration of colloids prior to ICU admission, administration of albumin prior to ICU admission, maximum white blood cell count, minimum platelet count, SAPS II without age or renal components, operative admission, and source of infection were significantly associated with KDIGO stage 2–3 AKI. (DOC 72 kb)

Logistic regression (“enter” method) in patients with septic shock (n = 478) in differing demographic variables, missing data imputed. Number (N) of imputed values and percentages of the cohort are given. Results of logistic regression in patients with septic shock showing that BMI, use of NSAID as daily medication, arteriosclerosis, COPD, administration of contrast medium prior to ICU admission, administration of colloids prior to ICU admission, SAPS II without age or renal components, operative admission, and source of infection were significantly associated with KDIGO stage 2–3 AKI. (DOC 53 kb)

Fulfillment of quality criterion by Clark et al. for genetic association studies, which were originally validated for AKI studies by Lu et al., and were later adapted by Vilander et al. Self-assessment of the study quality criteria is shown. (DOC 45 kb)

Association between acute kidney injury and the polymorphisms studied in all genotyped patients (nâ =â 2146) (additive genetic model). Association between acute kidney injury and the studied polymorphisms in all genotyped patients was tested in univariate and multivariate models. No significant associations are reported. (DOC 35 kb)

Demographic and baseline characteristics of the entire cohort according to the presence of acute kidney injury: the main demographic and baseline characteristics of the patients included in the FINNAKI genetic study. (DOC 86 kb)

Search strategy in Ovid Medline. (PDF 32Â kb)

PRISMA Checklist for systematic review. (PDF 117Â kb)

Articles studying AKI-related outcome. (PDF 213Â kb)

Search strategy in Embase. (PDF 33Â kb)

Quality scoring of the 28 full articles. (PDF 129Â kb)

Studies published only as abstracts. (PDF 205Â kb)

Articles studying AKI susceptibility. (PDF 243Â kb)

Supplemental material, Supplementary table 1 for The contribution of CACNA1A, ATP1A2 and SCN1A mutations in hemiplegic migraine: A clinical and genetic study in Finnish migraine families by Marjo Eveliina Hiekkala, Pietari Vuola, Ville Artto, Paavo Häppölä, Elisa Häppölä, Salli Vepsäläinen, Ester Cuenca-León, Dennis Lal, Padhraig Gormley, Eija Hämäläinen, Matti Ilmavirta, Markku Nissilä, Erkki Säkö, Marja-Liisa Sumelahti, Hanna Harno, Hannele Havanka, Petra Keski-Säntti, Markus Färkkilä, Aarno Palotie, Maija Wessman, Mari Anneli Kaunisto and Mikko Kallela in Cephalalgia

Supplemental material, Supplementary table 3 for The contribution of CACNA1A, ATP1A2 and SCN1A mutations in hemiplegic migraine: A clinical and genetic study in Finnish migraine families by Marjo Eveliina Hiekkala, Pietari Vuola, Ville Artto, Paavo Häppölä, Elisa Häppölä, Salli Vepsäläinen, Ester Cuenca-León, Dennis Lal, Padhraig Gormley, Eija Hämäläinen, Matti Ilmavirta, Markku Nissilä, Erkki Säkö, Marja-Liisa Sumelahti, Hanna Harno, Hannele Havanka, Petra Keski-Säntti, Markus Färkkilä, Aarno Palotie, Maija Wessman, Mari Anneli Kaunisto and Mikko Kallela in Cephalalgia