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1. Supplementary Figure 4. African ancestry in all genotyped Icelanders

Author

Jagadeesan, Anuradha, Gunnarsdóttir, Ellen D., S. Sunna Ebenesersdóttir, Guðmundsdóttir, Valdis B., Thordardottir, Elisabet Linda, Einarsdóttir, Margrét S., Jónsson, Hákon, Jean-Michel Dugoujon, Fortes-Lima, Cesar, Migot-Nabias, Florence, Massougbodji, Achille, Bellis, Gil, Pereira, Luisa, Másson, Gísli, Kong, Augustine, Stefánsson, Kári, and Helgason, Agnar

Abstract

A comparison of African ancestry estimates from HAPMIX and ADMIXTURE for (a) 17,199 chip-typed Icelanders born between 1880-1930 (b) 63,099 chip-typed Icelanders born between 1931-1960 and (c) 70,716 chip-typed Icelanders born between 1961-2017. Descendants of HJ are shown as red squares and other Icelanders are shown as black circles. See Supplementary Note for further details.

Published
2017
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2. Supplementary Figure 3. A comparison of African ancestry estimates from HAPMIX and ADMIXTURE for descendants of HJ

Author

Jagadeesan, Anuradha, Gunnarsdóttir, Ellen D., S. Sunna Ebenesersdóttir, Guðmundsdóttir, Valdis B., Thordardottir, Elisabet Linda, Einarsdóttir, Margrét S., Jónsson, Hákon, Jean-Michel Dugoujon, Fortes-Lima, Cesar, Migot-Nabias, Florence, Massougbodji, Achille, Bellis, Gil, Pereira, Luisa, Másson, Gísli, Kong, Augustine, Stefánsson, Kári, and Helgason, Agnar

Abstract

Estimates of African ancestry obtained from HAPMIX and ADMIXTURE were compared for the 182 genotyped descendants of HJ, yielding a correlation coefficient of r=0.9, p=4.1x10-66.

Published
2017
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3. Supplementary Figure 8. Chromosome drop simulation

Author

Jagadeesan, Anuradha, Gunnarsdóttir, Ellen D., S. Sunna Ebenesersdóttir, Guðmundsdóttir, Valdis B., Thordardottir, Elisabet Linda, Einarsdóttir, Margrét S., Jónsson, Hákon, Jean-Michel Dugoujon, Fortes-Lima, Cesar, Migot-Nabias, Florence, Massougbodji, Achille, Bellis, Gil, Pereira, Luisa, Másson, Gísli, Kong, Augustine, Stefánsson, Kári, and Helgason, Agnar

Abstract

The results from simulations where the transmission of African fragments from a single ancestor’s genome was examined, conditional on the genealogical structure that connects HJ to his 182 genotyped descendants. The figure shows the null distributions for the expected proportion of genome covered by fragments transmitted to the 182 descendants under three different assumptions about the African ancestry of HJ: 25% (green), 50 % (yellow) and 100 % (blue). The observed proportion (0.38) of genome covered by African fragments found in the 182 HJ descendants is shown as a red line.

Published
2017
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4. Supplementary Figure 7. Length distribution of African fragments

Author

Jagadeesan, Anuradha, Gunnarsdóttir, Ellen D., S. Sunna Ebenesersdóttir, Guðmundsdóttir, Valdis B., Thordardottir, Elisabet Linda, Einarsdóttir, Margrét S., Jónsson, Hákon, Jean-Michel Dugoujon, Fortes-Lima, Cesar, Migot-Nabias, Florence, Massougbodji, Achille, Bellis, Gil, Pereira, Luisa, Másson, Gísli, Kong, Augustine, Stefánsson, Kári, and Helgason, Agnar

Abstract

The length distribution in Mb of 674 African fragments identified using HAPMIX in HJ’s descendants. We have used blue (594) and red (80) colors to differentiate fragments being consistent or inconsistent with the genealogy.

Published
2017
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5. Supplementary Figure 6. Filtering African fragments

Author

Jagadeesan, Anuradha, Gunnarsdóttir, Ellen D., S. Sunna Ebenesersdóttir, Guðmundsdóttir, Valdis B., Thordardottir, Elisabet Linda, Einarsdóttir, Margrét S., Jónsson, Hákon, Jean-Michel Dugoujon, Fortes-Lima, Cesar, Migot-Nabias, Florence, Massougbodji, Achille, Bellis, Gil, Pereira, Luisa, Másson, Gísli, Kong, Augustine, Stefánsson, Kári, and Helgason, Agnar

Abstract

A flowchart showing the filtering procedure applied to African fragments identified using HAPMIX. Red arrows indicate a negative outcome whereas green arrows indicate positive outcome. Both are labelled by the number of fragments affected. Parental origin is abbreviated as PO, Hans Jonatan is abbreviated as HJ and genotyped ancestor is abbreviated as GA.

Published
2017
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6. Supplementary Figure 5. Local ancestry for chromosomes 6,12 and 2 in 150,832 chip-typed Icelanders

Author

Jagadeesan, Anuradha, Gunnarsdóttir, Ellen D., S. Sunna Ebenesersdóttir, Guðmundsdóttir, Valdis B., Thordardottir, Elisabet Linda, Einarsdóttir, Margrét S., Jónsson, Hákon, Jean-Michel Dugoujon, Fortes-Lima, Cesar, Migot-Nabias, Florence, Massougbodji, Achille, Bellis, Gil, Pereira, Luisa, Másson, Gísli, Kong, Augustine, Stefánsson, Kári, and Helgason, Agnar

Abstract

The distribution of African fragments identified by HAPMIX on (a) chromosome 6, (b) chromosome 12 and (c) chromosome 2 in Icelanders not descended from HJ. The distribution for the 320 individuals with evident African ancestry is shown in blue, whereas that of the remaining 150,512 individuals is shown in red. The upper plot (i), includes all fragments and the lower plot (ii), includes only fragments longer than 4Mb.

Published
2017
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7. Supplementary Note. African ancestry in Icelanders not descended from HJ

Author

Jagadeesan, Anuradha, Gunnarsdóttir, Ellen D., S. Sunna Ebenesersdóttir, Guðmundsdóttir, Valdis B., Thordardottir, Elisabet Linda, Einarsdóttir, Margrét S., Jónsson, Hákon, Jean-Michel Dugoujon, Fortes-Lima, Cesar, Migot-Nabias, Florence, Massougbodji, Achille, Bellis, Gil, Pereira, Luisa, Másson, Gísli, Kong, Augustine, Stefánsson, Kári, and Helgason, Agnar

Subjects
10. No inequality
Abstract

This supplementary note describes analyses undertaken to determine whether African fragments identified in descendants of HJ could be derived from other ancestors from the Icelandic population with African ancestry.

8. Supplementary Note. African ancestry in Icelanders not descended from HJ

Author

Jagadeesan, Anuradha, Gunnarsdóttir, Ellen D., S. Sunna Ebenesersdóttir, Guðmundsdóttir, Valdis B., Thordardottir, Elisabet Linda, Einarsdóttir, Margrét S., Jónsson, Hákon, Jean-Michel Dugoujon, Fortes-Lima, Cesar, Migot-Nabias, Florence, Massougbodji, Achille, Bellis, Gil, Pereira, Luisa, Másson, Gísli, Kong, Augustine, Stefánsson, Kári, and Helgason, Agnar

Subjects
10. No inequality
Abstract

This supplementary note describes analyses undertaken to determine whether African fragments identified in descendants of HJ could be derived from other ancestors from the Icelandic population with African ancestry.

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