1. International survey of T2* cardiovascular magnetic resonance in -thalassemia major
- Author
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Ana Almeida, Jane S. Hankins, Fernando Kay, Alexis A. Thompson, George Kontoghiorges, Chi Kong Li, John Paul Carpenter, Wing Y. Au, Mohsen Saleh Elalfy, M.D. Cappellini, Fabrice Danjou, Vassilis Ladis, Mirella Rangelova, Gian Luca Forni, Taigang He, J Malcolm Walker, Paul D. W. Kirk, Ru San Tan, Jameela Sathar, Michael Roughton, Lee Lee Chan, Shahina Daar, Tuncay Hazirolan, Andreas Michos, Meng-Yao Lu, Catherine Badens, Denka Stoyanova, Isabelle Thuret, Demetra Vini, Ali T. Taher, Manuela Merelles-Pulcini, V. John B. Porter, Ibrahim Al-Nasser, Winnie C.W. Chu, Amal El-Beshlawy, Antonis Kattamis, Lisa J. Anderson, Lia Wahidiyat, Valeria Kaleva, Georgi Tonev, Selen Bayraktaroglu, Renzo Galanello, Juliano L Fernandes, Shau Yin Ha, Khawla Belhoul, Dudley J. Pennell, Yesim Aydinok, Janet L. Kwiatkowski, Marouso Drossou, P. Joy Ho, Vassilios Perifanis, and Ege Üniversitesi
- Subjects
medicine.medical_specialty ,Internationality ,Iron Overload ,Thalassemia ,Magnetic Resonance Imaging, Cine ,Cohort Studies ,Internal medicine ,Humans ,Medicine ,Heart Failure ,medicine.diagnostic_test ,business.industry ,Data Collection ,beta-Thalassemia ,ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS ,International survey ,Beta thalassemia ,Magnetic resonance imaging ,Articles ,Hematology ,medicine.disease ,ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS ,ComputingMethodologies_PATTERNRECOGNITION ,Heart failure ,Cohort ,Cardiology ,InformationSystems_MISCELLANEOUS ,business ,β thalassemia major ,Cohort study - Abstract
PubMed ID: 23812939, Accumulation of myocardial iron is the cause of heart failure and early death in most transfused thalassemia major patients. T2* cardiovascular magnetic resonance provides calibrated, reproducible measurements of myocardial iron. However, there are few data regarding myocardial iron loading and its relation to outcome across the world. A survey is reported of 3,095 patients in 27 worldwide centers using T2* cardiovascular magnetic resonance. Data on baseline T2* and numbers of patients with symptoms of heart failure at first scan (defined as symptoms and signs of heart failure with objective evidence of left ventricular dysfunction) were requested together with more detailed information about patients who subsequently developed heart failure or died. At first scan, 20.6% had severe myocardial iron (T2*?10ms), 22.8% had moderate myocardial iron (T2* 10-20ms) and 56.6% of patients had no iron loading (T2*>20ms). There was significant geographical variation in myocardial iron loading (24.8-52.6%; P
- Published
- 2013
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