1. Gain of chromosome region 18q21 including the MALT1 gene is associated with the activated B-cell-like gene expression subtype and increased BCL2 gene dosage and protein expression in diffuse large B-cell lymphoma
- Author
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Eugenia Haralambieva, Swen Wessendorf, Wolfram Klapper, Carsten Schwaenen, Judith Dierlamm, Lorenz Trümper, Dido Lenze, Eva Maria Murga Penas, Hilmar Berger, Andreas Rosenwald, Markus W. Löffler, Rainer Spang, Stefan Bentink, Sergio Cogliatti, Peter Möller, Michael Hummel, Reiner Siebert, German Ott, and Harald Stein
- Subjects
Male ,Transcription, Genetic ,610 Medizin ,In situ hybridization ,Biology ,Gene dosage ,hemic and lymphatic diseases ,Gene expression ,medicine ,Humans ,In Situ Hybridization, Fluorescence ,B cell ,Aged ,ddc:610 ,B-Lymphocytes ,medicine.diagnostic_test ,Gene Expression Profiling ,Nucleic Acid Hybridization ,Hematology ,Middle Aged ,Prognosis ,medicine.disease ,Neoplasm Proteins ,Gene expression profiling ,MALT1 ,medicine.anatomical_structure ,Proto-Oncogene Proteins c-bcl-2 ,Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein ,Caspases ,Cancer research ,Female ,Lymphoma, Large B-Cell, Diffuse ,Chromosomes, Human, Pair 18 ,Diffuse large B-cell lymphoma ,Fluorescence in situ hybridization - Abstract
BACKGROUND: The aim of this study was to determine the impact of a gain of the MALT1 gene on gene expression and clinical parameters in diffuse large B-cell lymphoma. DESIGN AND METHODS: We analyzed 116 cases of diffuse large B-cell lymphoma by fluorescence in situ hybridization, array-based comparative genomic hybridization, and transcriptional profiling. RESULTS: A gain of 18q21 including MALT1 was detected in 44 cases (38%) and was accompanied by a gain of BCL2 in 43 cases. All cases with a 18q21/MALT1 gain showed BCL2 protein whereas 79% in the group without a 18q21/MALT1 gain did so (p
- Published
- 2008