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Start Over Author "Lodé L" Publisher ferrata storti foundation
7 results on '"Lodé L"'

1. Emergence and evolution of TP53 mutations are key features of disease progression in myelodysplastic patients with lower-risk del(5q) treated with lenalidomide.

Author

Lodé L, Ménard A, Flet L, Richebourg S, Loirat M, Eveillard M, Le Bris Y, Godon C, Theisen O, Gagez AL, Cartron G, Commes-Maerten T, Villemagne B, Luycx O, Godmer P, Pellat-Deceunynck C, Soussi T, Béné MC, Delaunay J, and Peterlin P

Subjects
Disease Progression, Female, Humans, Lenalidomide therapeutic use, Male, Middle Aged, Myelodysplastic Syndromes classification, Myelodysplastic Syndromes diagnosis, Prognosis, Chromosome Deletion, Chromosomes, Human, Pair 5, Mutation, Myelodysplastic Syndromes genetics, Tumor Suppressor Protein p53 genetics
Published
2018
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2. Single-molecule DNA sequencing of acute myeloid leukemia and myelodysplastic syndromes with multiple TP53 alterations.

Author

Lodé L, Ameur A, Coste T, Ménard A, Richebourg S, Gaillard JB, Le Bris Y, Béné MC, Lavabre-Bertrand T, and Soussi T

Subjects
Alleles, Genetic Association Studies, Genetic Predisposition to Disease, High-Throughput Nucleotide Sequencing, Humans, Leukemia, Myeloid, Acute mortality, Leukemia, Myeloid, Acute pathology, Leukemia, Myeloid, Acute therapy, Mutation, Myelodysplastic Syndromes mortality, Myelodysplastic Syndromes pathology, Myelodysplastic Syndromes therapy, Prognosis, Sequence Analysis, DNA, Genetic Variation, Leukemia, Myeloid, Acute genetics, Myelodysplastic Syndromes genetics, Tumor Suppressor Protein p53 genetics
Published
2018
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3. Use of killer cell immunoglobulin-like receptor genes as early markers of hematopoietic chimerism after double-umbilical cord blood transplantation.

Author

Rettman P, Legrand N, Willem C, Lodé L, Chevallier P, Cesbron A, Senitzer D, Retière C, and Gagne K

Subjects
Biomarkers blood, Female, Humans, Male, Cord Blood Stem Cell Transplantation, Polymorphism, Single Nucleotide, Receptors, KIR blood, Receptors, KIR genetics, Recovery of Function, Transplantation Chimera blood, Transplantation Chimera genetics
Published
2015
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4. Endogenous megakaryocytic colonies underline association between megakaryocytes and calreticulin mutations in essential thrombocythemia.

Author

Mondet J, Park JH, Menard A, Marzac C, Carillo S, Pourcelot E, Girodon F, Cabagnols X, Lodé L, Socoro N, Chauvet M, Bulabois CE, Cony-Makhoul P, Corm S, Cahn JY, and Mossuz P

Subjects
Alleles, Erythropoiesis genetics, Genetic Association Studies, Humans, Phenotype, Platelet Count, Thrombocythemia, Essential diagnosis, Thrombopoiesis genetics, Calreticulin genetics, Megakaryocytes metabolism, Mutation, Thrombocythemia, Essential genetics, Thrombocythemia, Essential metabolism
Published
2015
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5. The closely related rare and severe acute myeloid leukemias carrying EVI1 or PRDM16 rearrangements share singular biological features.

Author

Eveillard M, Delaunay J, Richebourg S, Lodé L, Garand R, Wuillème S, Duhoux F, Antoine-Poirel H, Godon C, and Béné MC

Subjects
Humans, DNA-Binding Proteins genetics, Gene Expression, Gene Rearrangement, Leukemia, Myeloid, Acute genetics, Leukemia, Myeloid, Acute mortality, Myeloid-Lymphoid Leukemia Protein genetics, Proto-Oncogenes genetics, Transcription Factors genetics
Published
2015
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7. Mutations in TP53 are exclusively associated with del(17p) in multiple myeloma.

Author

Lodé L, Eveillard M, Trichet V, Soussi T, Wuillème S, Richebourg S, Magrangeas F, Ifrah N, Campion L, Traullé C, Guilhot F, Caillot D, Marit G, Mathiot C, Facon T, Attal M, Harousseau JL, Moreau P, Minvielle S, and Avet-Loiseau H

Subjects
Chromosome Deletion, Chromosomes, Human, Pair 17, Disease-Free Survival, Female, Humans, Male, Risk Factors, Smith-Magenis Syndrome, Survival Rate, Gene Deletion, Multiple Myeloma genetics, Multiple Myeloma mortality, Tumor Suppressor Protein p53 genetics
Abstract

Deletion of the 17p13 chromosomal region [del(17p)] is associated with a poor outcome in multiple myeloma. Most of the studies have targeted the TP53 gene for deletion analyses, although no study showed that this gene is the deletion target. In order to address this issue, we sequenced the TP53 gene in 92 patients with multiple myeloma at diagnosis, 54 with a del(17p) and 38 lacking del(17p). At least one mutation was found in 20 patients, all of them presenting a del(17p). The analysis of the mutation location showed that virtually all of them occurred in highly conserved domains involved in the DNA-protein interactions. In conclusion, we showed that 37% of the myeloma patients with del(17p) present a TP53 mutation versus 0% in patients lacking the del(17p). The prognostic significance of these mutations remains to be evaluated.

Published
2010
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