1. [Hep-A-in-Vac, a Russian cultured concentrated inactivated vaccine against hepatitis A].
- Author
-
Gorbunov MA, Pavlova LI, Rozhkov SD, Kukharev AI, Novikov VIu, Karpovich LG, Kalashnikova TV, Bektimirov TA, Zelenov IA, Levina VD, Belashev BP, Ermolaeva TN, Doroshenko NV, and Maĭdaniuk AT
- Subjects
- Adolescent, Adult, Hepatitis A epidemiology, Hepatitis Antibodies blood, Hepatitis B Vaccines immunology, Humans, Male, Russia epidemiology, Time Factors, Vaccines, Inactivated adverse effects, Vaccines, Inactivated immunology, Vaccines, Synthetic immunology, Viral Hepatitis Vaccines adverse effects, Hepatitis A prevention & control, Hepatitis A Virus, Human immunology, Viral Hepatitis Vaccines immunology
- Abstract
The results of the study of the reactogenicity, safety and immunological activity of Russian cultural vaccine against hepatitis A are presented. The vaccine was found to have specific safety, moderate reactogenicity and pronounced immunological activity. In addition, the study of the prophylactic efficiency of the vaccine in the pre-epidemic period of the outbreak of hepatitis A morbidity in a group exceeding 14,000 adults was carried out. The study revealed high prophylactic efficiency of the vaccine (its efficiency rate was equal to 97.7%). On the basis of materials thus obtained vaccine "Hep-A-in-Vac" was recommended for use in medical practice for the prophylaxis of hepatitis A among adults.
- Published
- 1998