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1. [Analysis of the genetic constructs expressing antiviral siRNAs in the non-viral test system].

Author

Alembekov IR, Kretova OV, and Churikov NA

Subjects
Antiviral Agents, Biological Assay, Genome, Viral, HEK293 Cells, HIV-1 genetics, HIV-1 metabolism, Humans, RNA Interference, RNA, Viral genetics, Interferons metabolism, RNA, Small Interfering genetics, RNA, Small Interfering immunology, RNA, Small Interfering metabolism
Abstract

The efficiency of RNA interference triggered by the genetic constructs encoding siRNAs and directed against human immunodeficiency virus type 1 (HIV-1) transcripts was investigated in the non-viral test system. The investigation showed 6 biologically active siRNAs attacking 6 conservative targets in the HIV-1 genome. Expression of these genetic constructs failed to induce a nonspecific interferon response.

Published
2011

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