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Background. To evaluate the effectiveness of three courses of allergenspecific immunotherapy (ASIT) in children with combined forms of respiratory pollen allergy. Materials and methods. We observed 69 children aged 10,6±0,4 with combined forms of hay fever. All children were randomized and divided into 3 subgroups who received allergen-specific immunotherapy (ASIT) with Fostal, Staloral and water-salted mixed extracts of trees pollen. The comparison group consisted of 16 children with combined forms of hay fever without ASIT. The effectiveness of treatment was assessed by dynamics of the allergic rhino-conjunctivitis symptoms using a visual analogue scale and dynamics of the level of control over the symptoms of bronchial asthma using standardized questionnaires - the Asthma Control Test. Results. The first course of allergen-specific immunotherapy reduced the severity of rhinorrhea by 48%, nasal congestion - by 45,1%, itching eyes - by 40,8%, nasal itching - by 30,6%, complete control of asthma symptoms was achieved in 61,2%; ASIT reduced the likelihood of an uncontrolled flow of asthma in 17,6 times compared with children who did not receive immunotherapy. After three courses of allergen-specific immunotherapy with pollen allergens a decrease of the severity of allergic rhino-conjunctivitis symptoms and increase of the level of asthma symptoms control in all subgroups was shown.