1. IMMUNOEXPRESSION OF DEK AND PHOSPHO-P38 PROTEINS IN RECTAL CANCER BEFORE CHEMORADIATION THERAPY
- Author
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Rebeca De Barros TADOKORO, Leonardo CARDILI, Ricardo ARTIGIANI NETO, Ana Paula Ribeiro PAIOTTI, Celina Tizuko Fujiyama OSHIMA, and Nora Manoukian FORONES
- Subjects
Oncogene Proteins ,Phospho-P38 ,Chromosomal Proteins, Non-Histone ,Rectal Neoplasms ,Gastroenterology ,proto-oncogene DEK ,Adenocarcinoma ,Middle Aged ,Prognosis ,Immunohistochemistry ,immunohistochemistry ,Humans ,neoadjuvancy ,prognosis ,Rectal cancer ,chemoradiation ,Poly-ADP-Ribose Binding Proteins ,Neoplasm Staging - Abstract
Background: Colorectal cancer is the third cause of cancer worldwide and a quarter of them are in the rectum. DEK oncogene is involved in several nuclear processes and can accelerate tumorigenesis. Objective: This study aims to evaluate the immunoexpression of DEK and Phospho-P38 proteins before neoadjuvant therapy in patients with rectum adenocarcinoma and correlate it with a clinical response and survival. Methods: Patients with adenocarcinoma of the middle and low rectum who underwent chemotherapy and radiotherapy followed by surgical tumor resection were included. The expression and quantification were studied by immunohistochemistry in the tumor biopsy tissues using a HScore system. Score ≥4 were considered positive and those with
- Published
- 2022
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