1. Anca negative pauci-immune crescentic glomerulonephritis and mixed connective tissue disease: a case study
- Author
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João Cardoso, Sónia Carina Silva, Sara Fernandes, Edgar Almeida, Luis Falcao, Ana Cortesão Costa, Mário Raimundo, and Catarina Teixeira
- Subjects
Pathology ,medicine.medical_specialty ,030232 urology & nephrology ,Case Report ,lcsh:RC870-923 ,urologic and male genital diseases ,Serology ,03 medical and health sciences ,Glomerulonephritis ,0302 clinical medicine ,Mixed connective tissue disease ,immune system diseases ,medicine ,Rapidly progressive glomerulonephritis ,cardiovascular diseases ,Anca negative ,skin and connective tissue diseases ,Mixed Connective Tissue Disease ,030203 arthritis & rheumatology ,biology ,business.industry ,Crescentic glomerulonephritis ,General Medicine ,lcsh:Diseases of the genitourinary system. Urology ,medicine.disease ,respiratory tract diseases ,Glomerulonefrite ,Doença Mista do Tecido Conjuntivo ,Pauci-immune ,biology.protein ,medicine.symptom ,Antibody ,business - Abstract
One of the most common causes of rapidly progressive glomerulonephritis (RPGN) is pauci-immune crescentic glomerulonephritis (CrGN). In the majority of cases, this condition has a positive serologic marker, the anti-neutrophil cytoplasmic antibodies (ANCAs), but in approximately 10% there are no circulating ANCAs, and this subgroup has been known as the ANCA-negative pauci-immune CrGN. RPGN can be associated with systemic diseases, but there are only few case reports describing the association with mixed connective tissue disease (MCTD). The authors report a case of ANCA-negative CrGN associated with a MCTD.
- Published
- 2020
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