1. Placenta specific gene targeting to study histone lysine demethylase and androgen signaling in ruminant placenta
- Author
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Agata M. Parsons Aubone, Taylor Kimberly Hord, Jason E. Bruemmer, Asghar Ali, Quinton A Winger, River Evans, Gerrit J. Bouma, and Hayley Nicole Templeton
- Subjects
placenta ,Biology ,Thematic Section: 34th Annual Meeting of the Brazilian Embryo Technology Society (SBTE) ,03 medical and health sciences ,0302 clinical medicine ,androgen receptor ,Placenta ,medicine ,Gene knockdown ,030219 obstetrics & reproductive medicine ,General Veterinary ,0402 animal and dairy science ,Placentation ,Gene targeting ,KDM1A ,04 agricultural and veterinary sciences ,trophoblast cells ,040201 dairy & animal science ,Cell biology ,Androgen receptor ,Histone ,medicine.anatomical_structure ,biology.protein ,Demethylase ,Animal Science and Zoology - Abstract
Reproductive efficiency is critically dependent on embryo survival, establishment of a successful pregnancy and placental development. Recent advances in gene editing technology have enabled investigators to use gene knockdown and knockout approaches to better understand the role of hormone signaling in placental function and fetal growth and development. In this review, an overview of ruminant placentation will be provided, including recent data highlighting the role of histone lysine demethylase 1A and androgen signaling in ruminant placenta and pregnancy. Studies in ruminant placenta establish a role for histone lysine demethylase 1A in controlling genetic networks necessary for important cellular events such as cell proliferation and angiogenesis, as well as androgen receptor signaling during early placentation.
- Published
- 2020
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