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Bovine mastitis provokes inflammation of the mammary gland and is mainly caused by Staphylococcus aureus. Highest incidence occurs at drying off period and parturition, where prolactin (PRL) has a relevant function, although its role in the infection has not been studied. In this work, in vitro effect of the bovine PRL (1-50 ng/mL) on endocytosis and intracellular proliferation of S. aureus (ATCC 27543) in bovine mammary epithelial cells (BMEC) was evaluated. The BMEC treated during 24 h with 5 ng/mL of bPRL increases ~3 fold the endocytosis of S. aureus, besides inducing bacterial proliferation. This effect was specifically reverted by treating the BMEC with IgG anti-bPRL. S. aureus increased (~3 fold) its endocytosis in BMEC treated with bPRL (5 ng/mL), but the number of infected cells was not modified. In conclusion, the bPRL stimulates the endocytosis and the proliferation of S. aureus in BMEC. i [ABSTRACT FROM AUTHOR]

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