1. Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital
- Author
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Carlos Alberto Buchpiguel, Mayra de Barros Dorna, Lisa Suzuki, Sofia Mendes Sieczkowska, Marlene Pereira Garanito, Marta Imamura, Camila Sanson Yoshino de Paula, Marcos S Lima, Jorge David Aivazoglou Carneiro, Priscila Suguita, Lucia M.A. Campos, Andreia Watanabe, Adriana M. E. Sallum, Sylvia Costa Lima Farhat, Fernanda de Toledo Gonçalves, Deipara Monteiro Abellan, Bruna Caruzo, Ricardo Katsuya Toma, Joaquim C. Rodrigues, Denise Matheus, Linamara Rizzo Batisttella, Guilherme V. Polanczyk, Isabela G. Marques, Vicente Odone Filho, Inar Alves de Castro, Angélica Carreira dos Santos, Fernando D. Penteado, Livia Lindoso, Carolina C M F Martins, Juliana Carvalho Ferreira, Magda Carneiro-Sampaio, Vitor Cavalcanti Trindade, Fabiana Braga Benatti, Rosa Maria Rodrigues Pereira, Katia Kozu, Nadia E. Aikawa, Nadia Litvinov, Hamilton Roschel, Marcelo Tatit Sapienza, Lucas V B Souza, Ana Claudia Latronico Xavier, Bruno Gualano, Patricia Palmeira, Paula Lage Pasqualucci, Olivia M Matsuo, Fernanda O. Martins, Maria Fernanda Badue Pereira, Izabel M. Buscatti, Amanda Ihara, Yingying Zheng, Silvana Forsait, Lilian Maria Cristofani, Paula V V Gaiolla, Thais de Toledo Fink, Fabiana Smaria, Carina Ceneviva, Kátia Regina da Silva, Alexandra Brentani, José Albino da Paz, Heloisa Helena de Souza Marques, Leila Antonangelo, Simone Correa-Silva, Guilherme S Gonçalves, Álvaro José dos Santos Neto, Jarlei Fiamoncini, Clovis A. Silva, Bernadette Dora Gombossy de Melo Franco, Neusa Keico Sakita, Gabriela Salim de Castro, Vera Aparecida dos Santos, Gabriela Nunes Leal, Camilla Astley, Márcia F A Santos, Juliana Caires de Oliveira Achili Ferreira, Antonio Carlos Pastorino, Andrea R Santos, Ana Pinheiro Machado Canton, Marilia Seelaender, Danilo Marcelo Leite do Prado, Carlos Roberto Ribeiro de Carvalho, Vera Bain, Karina Lucio de Medeiros Bastos, Ilana Roitman Disi, Luiz V. R. F. Silva Filho, Alberto José da Silva Duarte, and Jaline Z Faiad
- Subjects
Male ,medicine.medical_specialty ,Medicine (General) ,Long Coronavirus Disease 2019 ,Coronavirus disease 2019 (COVID-19) ,Adolescent ,Anemia ,Multisystem Inflammatory Syndrome in Children ,Tertiary Care Centers ,Sequelae ,COVID-19 Testing ,Post-Acute COVID-19 Syndrome ,R5-920 ,Quality of life ,Internal medicine ,medicine ,Humans ,Prospective Studies ,Prospective cohort study ,Child ,ANTROPOMETRIA ,Health related quality of life ,business.industry ,SARS-CoV-2 ,COVID-19 ,General Medicine ,Anthropometry ,medicine.disease ,Latin America ,Quality of Life ,Original Article ,Observational study ,business ,Body mass index - Abstract
OBJECTIVES: To prospectively evaluate demographic, anthropometric and health-related quality of life (HRQoL) in pediatric patients with laboratory-confirmed coronavirus disease 2019 (COVID-19) METHODS: This was a longitudinal observational study of surviving pediatric post-COVID-19 patients (n=53) and pediatric subjects without laboratory-confirmed COVID-19 included as controls (n=52) was performed. RESULTS: The median duration between COVID-19 diagnosis (n=53) and follow-up was 4.4 months (0.8-10.7). Twenty-three of 53 (43%) patients reported at least one persistent symptom at the longitudinal follow-up visit and 12/53 (23%) had long COVID-19, with at least one symptom lasting for >12 weeks. The most frequently reported symptoms at the longitudinal follow-up visit were headache (19%), severe recurrent headache (9%), tiredness (9%), dyspnea (8%), and concentration difficulty (4%). At the longitudinal follow-up visit, the frequencies of anemia (11% versus 0%, p=0.030), lymphopenia (42% versus 18%, p=0.020), C-reactive protein level of >30 mg/L (35% versus 0%, p=0.0001), and D-dimer level of >1000 ng/mL (43% versus 6%, p=0.0004) significantly reduced compared with baseline values. Chest X-ray abnormalities (11% versus 2%, p=0.178) and cardiac alterations on echocardiogram (33% versus 22%, p=0.462) were similar at both visits. Comparison of characteristic data between patients with COVID-19 at the longitudinal follow-up visit and controls showed similar age (p=0.962), proportion of male sex (p=0.907), ethnicity (p=0.566), family minimum monthly wage (p=0.664), body mass index (p=0.601), and pediatric pre-existing chronic conditions (p=1.000). The Pediatric Quality of Live Inventory 4.0 scores, median physical score (69 [0-100] versus 81 [34-100], p=0.012), and school score (60 [15-100] versus 70 [15-95], p=0.028) were significantly lower in pediatric patients with COVID-19 at the longitudinal follow-up visit than in controls. CONCLUSIONS: Pediatric patients with COVID-19 showed a longitudinal impact on HRQoL parameters, particularly in physical/school domains, reinforcing the need for a prospective multidisciplinary approach for these patients. These data highlight the importance of closer monitoring of children and adolescents by the clinical team after COVID-19.
- Published
- 2021