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The Vogt-Koyanagi-Harada disease is an unusual affection, characterized by a meningeal syndrome, an ocular syndrome involving the anterior or posterior segment of the eye, and at last, manifestations of skin involvement such as poliosis, vitiligo and alopecia. Nowadays, the physiopathologic hypothesis, the most admitted, is the one of auto-immune process regarding the uveal pigment. Nosologically speaking, clinical epidemiologic and etiopathogenic arguments have allowed to join the Harada and Vogt-Koyanagi diseases under the same name: the Vogt-Koyanagi-Harada disease. The same arguments, except the epidemiologic ones, allow to make a similarity between this affection and uveo-meningitis on the hand, sympathetic ophthalmitis on the other hand. The use of oral corticosteröids and eventually immuno-suppressive agents constitute the only therapeutic methods, nowadays.

The possibility of cutaneous manifestations in Down's syndromes not a surprise because we known that this affection affects the three embryonic parts. This cutaneous disorder is described by many authors but it is variable and not specific. The authors had occasion to see four cases of alopecia areata in mongolian children. They do an analytic study of variable manifestations. They insist on frequency of hyperkeratotic lesions, alopecia areata, alterations of vasomotricity and elastic dystrophies. In the group of chromosomic aberrations, down's syndrome is alone where the cutaneous manifestations are studied because the patients have a good survival.

The authors report 4 cases of multiple tumors of the lumbo-sacral region with, on histology, a mixture of basal cell carcinomas and fibro-epithelial Pinkus tumours. They were struck by the fact that three of these four patients had received, in this region, radiotherapy numerous years previously. They discuss the role of this radiotherapy in the onset of the disease and the relative importance of this factor and of constitutional factors (Hamartomas). They recall the characteristics of multiple basal cell carcinomas and of Pinkus fibro-epithelial tumours, together with the close relationship between these two types of tumour.

Among the systemic manifestations of Behçet's syndrome, venous and arterial involvements are discussed. Venous thrombosis is a common manifestation and may be considered as a cardinal sign in the diagnosis. Venous and arterial thrombotic complications may be regarded as agents of morbidity and mortality. The pathogenesis of the occlusive process is still some what obscure, although vasculitis and impaired local vascular fibrinolytic activity play a part in it. Therapeutic measures using fibrinolytic enhancing agents may prevent and control the thrombotic complications of the disease.