1. Performance of candidate urinary biomarkers for pancreatic cancer - Correlation with pancreatic cyst malignant progression?
- Author
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Yip-Schneider MT, Soufi M, Carr RA, Flick KF, Wu H, Colgate CL, and Schmidt CM
- Subjects
- Adenocarcinoma, Mucinous surgery, Adult, Aged, Carcinoma, Pancreatic Ductal surgery, Disease Progression, Female, Humans, Male, Middle Aged, Pancreatic Cyst surgery, Prostaglandins E urine, Tissue Inhibitor of Metalloproteinase-1 urine, Vesicular Transport Proteins urine, Adenocarcinoma, Mucinous urine, Biomarkers, Tumor urine, Carcinoma, Pancreatic Ductal urine, Pancreatic Cyst urine, Pancreatic Neoplasms surgery, Pancreatic Neoplasms urine
- Abstract
Background: Intraductal papillary mucinous neoplasms (IPMN) are precursors of pancreatic cancer. Potential biomarkers of IPMN progression have not been identified in urine. A few urinary biomarkers were reported to be predictive of pancreatic ductal adenocarcinoma (PDAC). Here, we seek to assess their ability to detect high-risk IPMN., Methods: Urine was collected from patients undergoing pancreatic resection and healthy controls. TIMP-1(Tissue Inhibitor of Metalloproteinase-1), LYVE-1(Lymphatic Vessel Endothelial Receptor 1), and PGEM(Prostaglandin E Metabolite) levels were determined by ELISA and analyzed by Kruskal-Wallis., Results: Median urinary TIMP-1 levels were significantly lower in healthy controls (n = 9; 0.32 ng/mg creatinine) compared to PDAC (n = 13; 1.95) but not significantly different between low/moderate-grade (n = 20; 0.71) and high-grade/invasive IPMN (n = 20; 1.12). No significant difference in urinary LYVE-1 was detected between IPMN low/moderate (n = 16; 0.37 ng/mg creatinine) and high/invasive grades (n = 21; 0.09). Urinary PGEM levels were not significantly different between groups., Conclusions: Urinary TIMP-1, LYVE-1, and PGEM do not correlate with malignant potential of pancreatic cysts., (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Published
- 2020
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