1. Locally advanced pancreatic cancer: Is surgical palliation associated with improved clinical outcome relative to medical palliation?
- Author
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Kramer SP, Tonelli C, Luchette FA, Swanson J, Abdelsattar Z, Cohn T, and Baker MS
- Subjects
- Humans, Palliative Care methods, Retrospective Studies, Pancreas, Pancreatic Neoplasms surgery
- Abstract
Background: The value of palliative surgery in pancreatic cancer is not well-defined., Methods: We queried the National Cancer Database for patients undergoing curative-intent resection, palliative surgery or medical palliation for clinical stage cT4N0-2M0 pancreatic cancer. Cohorts were 1:1:1 propensity-score-matched for comorbidities and stage. Kaplan-Meier method was used to compare overall survival for matched cohorts., Results: 9,107 patients met inclusion criteria: 3,567 (39 %) underwent curative intent surgery, 1608 (18 %) surgical palliation, 3932 (43 %) medical palliation. Patients undergoing resection and surgical palliation had significant hospitalizations (11.0 ± 0.4 vs. 10.0 ± 0.3 days; p = 0.821) and rates of readmission (8.1 % vs. 2.0 %; p < 0.001). Patients undergoing surgical palliation demonstrated marginal increases in survival relative to those undergoing medical palliation (8.54 vs. 7.36 months; p < 0.0001)., Conclusion: In patients undergoing care for locally advanced pancreatic cancer, palliative surgery is associated with marginal improvement in survival but significant lengths of hospitalization and risk of readmission., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Published by Elsevier Inc.)
- Published
- 2024
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