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Richard W. Troughton, Said Laribi, Erwin Hansconrad, Justina Motiejunaite, Mehmet Yilmaz, Christian Mueller, Semir Nouira, Kenan Ahmet Turkdogan, Agim Beshiri, Wenjia Chen, Zaid Sabti, Chris J. Pemberton, Alexandre Mebazaa, J. Mark FitzGerald, Jean-Marie Launay, Malha Sadoune, Lyndsey Kirwan, Mercedes Rivas-Lasarte, Corinne Collet, Patrick Plaisance, Mark Richards, Etienne Gayat, Biomarqueurs CArdioNeuroVASCulaires (BioCANVAS), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de Médecine d'Urgence [CHU Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Ecole de Médecine [Tours], Université de Tours (UT), Department of Medicine [Christchurch, New Zealand], University of Otago [Dunedin, Nouvelle-Zélande], Emergency Dept and Research Unit UR06SP21 [Monastir, Tunisia], CHU Fattouma Bourguiba [Monastir] (HFB), Department of Emergeny Medicine [Aydin, Turkey], Adnan Menderes Üniversitesi, Department of Cardiology [Sivas, Turkey], Cumhuriyet University [Sivas, Turkey], Université Sorbonne Paris Cité (USPC), Service d'Anesthésie-Réanimation [AP-HP Hôpitaux Saint-Louis Lariboisière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Cardiology Department [Barcelona, Spain], Hospital de la Santa Creu i Sant Pau, Department of Internal Medicine [Basel, Switzerland], University Hospital Basel [Basel], Département de Médecine d'Urgence [AP-HP Hôpitaux universitaires Saint-Louis, Lariboisière, Fernand-Widal], AP-HP Hôpitaux universitaires Saint-Louis, Lariboisière, Fernand-Widal, Department of Cardiology [Kaunas, Lithuania], Hospital of Lithuanian University of Health Sciences Kauno Klinikos [Kaunas, Lithuania], Medical and Scientific Affairs [Abbott Park, IL, USA], Abbott Laboratories, Respiratory Division [Vancouver, BC, Canada], University of British Columbia - UBC [Vancouver, BC, Canada], Service de Biochimie [AP-HP Hôpitaux Saint-Louis Lariboisière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], UBC and VGH Divisions of Respiratory Medicine [Vancouver, BC, Canada], St. Paul’s Hospital - University of British Columbia [Vancouver, BC, Canada]-Institute for Heart and Lung Health [Vancouver, BC, Canada], Cardiovascular Research Institute [Singapour], National University of Singapore (NUS), Vilnius University [Lithuania], This study was funded by ThermoFisher. A. Mebazaa and J. Motiejunaite would like to acknowledgethe support of the Research Council of Lithuania, grant number MIP-049/2015., Université Paris Diderot - Paris 7 (UPD7), Service de biochimie INSERM UMR-S942, Hôpital Lariboisière-APHP, Service des Urgences, Hôpital Lariboisière, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Institut fuer Theoretische Physik (Institut fuer Theoretische Physik), Universität Heidelberg [Heidelberg], U942, Hop Lariboisiere, AP HP,Dept Biochem, Institut National de la Santé et de la Recherche Médicale (INSERM), Département d'Anesthésie Réanimation SMUR [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], St. Paul’s Hospital - University of British Columbia [Vancouver, BC, Canada] (SPH-UBC)-Institute for Heart and Lung Health [Vancouver, BC, Canada], Mebazaa, Alexandre, Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Université de Tours, Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), [Laribi, Said] Francois Rabelais Univ, Sch Med, Tours, France -- [Laribi, Said] Tours Univ Hosp, Emergency Med Dept, Tours, France -- [Laribi, Said -- Kirwan, Lyndsey -- Gayat, Etienne -- Rivas-Lasarte, Mercedes -- Sadoune, Malha -- Motiejunaite, Justina -- Plaisance, Patrick -- Launay, Jean-Marie -- Mebazaa, Alexandre] INSERM, U942, BIOmarkers CArdioNeuroVASc Dis, Paris, France -- [Pemberton, Chris J. -- Troughton, Richard W. -- Richards, Mark] Univ Otago, Dept Med, Christchurch Heart Inst, Christchurch, New Zealand -- [Nouira, Semir] Fattouma Bourguiba Univ Hosp, Emergency Dept, Monastir, Tunisia -- [Nouira, Semir] Fattouma Bourguiba Univ Hosp, Res Unit UR06SP21, Monastir, Tunisia -- [Turkdogan, Kenan] Adnan Menderes Univ, Fac Med, Dept Emergeny Med, Aydin, Turkey -- [Yilmaz, Mehmet Birhan] Cumhuriyet Univ, Fac Med, Dept Cardiol, Sivas, Turkey -- [Gayat, Etienne -- Plaisance, Patrick -- Mebazaa, Alexandre] Univ Paris Diderot, Sorbonne Paris Cite, Paris, France -- [Gayat, Etienne -- Motiejunaite, Justina -- Mebazaa, Alexandre] St Louis Lariboisiere Hosp, AP HP, Dept Anesthesiol & Crit Care, Paris, France -- [Rivas-Lasarte, Mercedes] Univ Autonoma Barcelona, Biomed Res Inst IIB St Pau, Hosp Santa CreuiSt Pau, Cardiol Dept, Barcelona, Spain -- [Sabti, Zaid -- Mueller, Christian] Univ Hosp, Dept Internal Med, Basel, Switzerland -- [Hansconrad, Erwin -- Plaisance, Patrick] St Louis Lariboisiere Hosp, AP HP, Emergency Med Dept, Paris, France -- [Motiejunaite, Justina] Lithuanian Univ Hlth Sci Kauno Klinikos, Dept Cardiol, Kaunas, Lithuania -- [Beshiri, Agim] Abbott Labs, Abbott Pk, IL 60064 USA -- [Chen, Wenjia] Univ British Columbia, Resp Div, Inst Heart & Lung Hlth, Vancouver, BC, Canada -- [Collet, Corinne] St Louis Lariboisiere Hosp, AP HP, Dept Biochem, Paris, France -- [FitzGerald, J. Mark] Inst Heart & Lung Hlth, UBC Div Resp Med, Vancouver, BC, Canada -- [FitzGerald, J. Mark] Inst Heart & Lung Hlth, VGH Div Resp Med, Vancouver, BC, Canada -- [Richards, Mark] Natl Univ Singapore, Cardiovasc Res Inst, Singapore, Singapore -- [Mebazaa, Alexandre] Vilnius Univ, Vilnius, Lithuania, YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628, YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628, Chen, Wenjia -- 0000-0001-8201-7145, GAYAT, Etienne -- 0000-0002-3334-3849, Mebazaa, Alexandre -- 0000-0001-8715-7753, and collet, corinne -- 0000-0001-6990-863X