6 results on '"Thivolet-Béjui, F."'
Search Results
2. Diagnosis and management of idiopathic pulmonary fibrosis: French practical guidelines.
- Author
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Cottin V, Crestani B, Valeyre D, Wallaert B, Cadranel J, Dalphin JC, Delaval P, Israel-Biet D, Kessler R, Reynaud-Gaubert M, Aguilaniu B, Bouquillon B, Carré P, Danel C, Faivre JB, Ferretti G, Just N, Kouzan S, Lebargy F, Marchand-Adam S, Philippe B, Prévot G, Stach B, Thivolet-Béjui F, and Cordier JF
- Subjects
- Consensus, Diagnostic Imaging standards, Evidence-Based Medicine standards, France epidemiology, Humans, Idiopathic Pulmonary Fibrosis epidemiology, Predictive Value of Tests, Risk Factors, Treatment Outcome, Idiopathic Pulmonary Fibrosis diagnosis, Idiopathic Pulmonary Fibrosis therapy, Pulmonary Medicine standards
- Abstract
Idiopathic pulmonary fibrosis (IPF) is the most frequent chronic idiopathic interstitial pneumonia in adults. The management of rare diseases in France has been organised by a national plan for rare diseases, which endorsed a network of expert centres for rare diseases throughout France. This article is an overview of the executive summary of the French guidelines for the management of IPF, an initiative that emanated from the French National Reference Centre and the Network of Regional Competence Centres for Rare Lung Diseases. This review aims at providing pulmonologists with a document that: 1) combines the current available evidence; 2) reviews practical modalities of diagnosis and management of IPF; and 3) is adapted to everyday medical practice. The French practical guidelines result from the combined efforts of a coordination committee, a writing committee and a multidisciplinary review panel, following recommendations from the Haute Autorité de Santé. All recommendations included in this article received at least 90% agreement by the reviewing panel. Herein, we summarise the main conclusions and practical recommendations of the French guidelines., (©ERS 2014.)
- Published
- 2014
- Full Text
- View/download PDF
3. Hypereosinophilic obliterative bronchiolitis: a distinct, unrecognised syndrome.
- Author
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Cordier JF, Cottin V, Khouatra C, Revel D, Proust C, Freymond N, Thivolet-Béjui F, and Glérant JC
- Subjects
- Adult, Biopsy, Bronchoalveolar Lavage Fluid, Eosinophils cytology, Female, Humans, Hypereosinophilic Syndrome diagnosis, Hypersensitivity, Leukocyte Count, Male, Middle Aged, Respiratory Function Tests, Retrospective Studies, Syndrome, Tomography, X-Ray Computed, Bronchiolitis Obliterans classification, Bronchiolitis Obliterans diagnosis, Eosinophilia diagnosis, Pneumonia diagnosis
- Abstract
Biopsy-proven cases of eosinophilic bronchiolitis have only been reported in isolation, and all come from Japan. We present six patients with hypereosinophilic obliterative bronchiolitis (HOB), defined by the following criteria: 1) blood eosinophil cell count >1 G·L(-1) and/or bronchoalveolar lavage eosinophil count >25%; 2) persistent airflow obstruction despite high-dose inhaled bronchodilators and corticosteroids; and 3) eosinophilic bronchiolitis at lung biopsy (n=1) and/or direct signs of bronchiolitis (centrilobular nodules and branching opacities) on computed tomography (n=6). Chronic dyspnoea and cough which was often severe, without the characteristic features of asthma, were the main clinical manifestations. Atopy and asthma were present in the history of three and two patients, respectively. One patient met biological criteria of the lymphoid variant of idiopathic hypereosinophilic syndrome. Mean blood eosinophil cell count was 2.7 G·L(-1) and mean eosinophil differential percentage at bronchoalveolar lavage was 63%. Mean initial forced expiratory volume in 1 s/forced vital capacity ratio was 50%, normalising with oral corticosteroid therapy in all patients. HOB manifestations recurred when oral prednisone was decreased to 10-20 mg·day(-1), but higher doses controlled the disease. HOB is a characteristic entity deserving to be individualised among the eosinophilic respiratory disorders. Thorough analysis is needed to determine whether unrecognised and/or smouldering HOB may further be a cause of irreversible airflow obstruction in chronic eosinophilic respiratory diseases.
- Published
- 2013
- Full Text
- View/download PDF
4. Telomerase activation in a model of lung adenocarcinoma.
- Author
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Suau F, Cottin V, Archer F, Croze S, Chastang J, Cordier G, Thivolet-Béjui F, Mornex JF, and Leroux C
- Subjects
- Adenocarcinoma, Bronchiolo-Alveolar pathology, Animals, Cell Division genetics, Cell Transformation, Neoplastic genetics, Cell Transformation, Neoplastic pathology, Cellular Senescence genetics, Enzyme Activation genetics, Gene Expression Regulation genetics, Humans, Lung pathology, Proto-Oncogene Proteins c-akt genetics, Pulmonary Alveoli pathology, Sheep, Signal Transduction genetics, Tumor Cells, Cultured pathology, Adenocarcinoma genetics, Adenocarcinoma, Bronchiolo-Alveolar genetics, Disease Models, Animal, Jaagsiekte sheep retrovirus genetics, Lung Neoplasms genetics, Pulmonary Adenomatosis, Ovine genetics, Telomerase genetics
- Abstract
Ovine pulmonary adenocarcinoma (OPA) is a lung cancer strikingly similar to the pneumonic-type mixed invasive adenocarcinoma with a predominant bronchioloalveolar component in humans. Telomerase activity in OPA and the potential involvement of the kinase Akt in telomerase activation and regulation of cell proliferation were investigated. Lung tissues were collected from sheep with a histopathological diagnosis of OPA or controls. Epithelial cell cultures were derived in vitro from lung tissues. Telomerase activity was evaluated using the telomeric repeat amplification protocol method. Phosphorylation of Akt was detected by Western blotting. Telomerase activity was significantly higher in OPA lung tissues compared to control lung tissues. A high telomerase activity was detected in eight out of 12 (67%) primary cell cultures derived from tumours. A high level of expression of phosphorylated Akt was found in 10 out of 27 (37%) tumours, with abolition of Akt activation in response to epidermal growth factor stimulation demonstrated in primary cell cultures derived from tumours. Telomerase activation takes place in ovine pulmonary adenocarcinoma tumour cells and may be partly attributable to Akt activation. Telomerase may inhibit cellular senescence and contribute to the accumulation of tumour cells in mixed adenocarcinoma with a bronchioloalveolar component. Further work is necessary to identify alternative signalling pathways of telomerase activation in tumours.
- Published
- 2006
- Full Text
- View/download PDF
5. Interstitial lung disease in amyopathic dermatomyositis, dermatomyositis and polymyositis.
- Author
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Cottin V, Thivolet-Béjui F, Reynaud-Gaubert M, Cadranel J, Delaval P, Ternamian PJ, and Cordier JF
- Subjects
- Adult, Aged, Dermatomyositis therapy, Female, Humans, Lung pathology, Lung Diseases, Interstitial therapy, Male, Middle Aged, Retrospective Studies, Time Factors, Treatment Outcome, Dermatomyositis complications, Dermatomyositis pathology, Lung Diseases, Interstitial etiology, Lung Diseases, Interstitial pathology, Muscle, Skeletal pathology, Skin pathology
- Abstract
This study investigated interstitial pneumonia associated with amyopathic dermatomyositis, dermatomyositis and polymyositis, paying particular attention to muscular and/or cutaneous manifestations and their chronology relative to lung involvement. Patients included four males and 13 females, aged 51.7+/-10.8 yrs, who had surgical lung biopsy. Diagnoses included dermatomyositis (10 patients), polymyositis (four patients) and amyopathic dermatomyositis (three patients). Solitary respiratory manifestations preceded the onset of any skin or muscle disease in four cases (24%). Reticular and ground glass opacities were the most frequent computed tomography (CT) findings. Pathological review showed nonspecific interstitial pneumonia (eleven, 65%; cellular, two; cellular and fibrotic, five; fibrotic, four), usual interstitial pneumonia (two), organising pneumonia (two), lymphocytic interstitial pneumonia (one), and unclassifiable interstitial pneumonia (one). Nonspecific interstitial pneumonia was the most common histological pattern of interstitial pneumonia in patients with amyopathic dermatomyositis (three of three) and in patients with respiratory symptoms as the initial clinical manifestation of the connective tissue disease (three of four). Survival at 5 yrs was 50%. This study shows the clinician should remain alert to potential muscular or cutaneous manifestations whenever a pathological diagnosis of nonspecific interstitial pneumonia is made.
- Published
- 2003
- Full Text
- View/download PDF
6. Lymphomatoid granulomatosis--a report on four cases: evidence for B phenotype of the tumoral cells.
- Author
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Tanière P, Thivolet-Béjui F, Vitrey D, Isaac S, Loire R, Cordier JF, and Berger F
- Subjects
- Adult, Antigens, CD analysis, Epstein-Barr Virus Infections diagnosis, Epstein-Barr Virus Infections pathology, Epstein-Barr Virus Nuclear Antigens analysis, Female, Humans, Immunoenzyme Techniques, In Situ Hybridization, Lung pathology, Lung Neoplasms diagnosis, Lung Neoplasms pathology, Lymphomatoid Granulomatosis diagnosis, Lymphomatoid Granulomatosis pathology, Lysosomal Membrane Proteins, Male, Membrane Glycoproteins analysis, Middle Aged, B-Lymphocytes pathology, Epstein-Barr Virus Infections genetics, Lung Neoplasms genetics, Lymphomatoid Granulomatosis genetics
- Abstract
Four cases of lymphomatoid granulomatosis are reported, three of them involving the lung. Histological features included a true angiocentric and angiodestructive polymorphic cellular proliferation. This included histiocytes, plasma cells, many reactive T-cells and rare large, atypical cells which were of the B phenotype. Epstein-Barr virus was detected in the atypical cells by in situ hybridization in three cases, with expression of both latent membrane proteins (LMP)-1 and Epstein-Barr nuclear antigen-2 in two cases and expression of only LMP-1 in the third case. Expression of both of these proteins suggests a defect in the T-cell-mediated immunity and that Epstein-Barr virus is not only a silent passenger but may also be involved in the pathogenesis of the disease. This could have implications for therapy.
- Published
- 1998
- Full Text
- View/download PDF
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