1. Biomarkers of carcinogenesis and tumour growth in patients with cutaneous melanoma and obstructive sleep apnoea.
- Author
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Santamaria-Martos F, Benítez I, Girón C, Barbé F, Martínez-García MA, Hernández L, Montserrat JM, Nagore E, Martorell A, Campos-Rodriguez F, Corral J, Cabriada V, Abad J, Mediano O, Troncoso MF, Cano-Pumarega I, Fortuna Gutierrez AM, Diaz-Cambriles T, Somoza-Gonzalez M, Almendros I, Farre R, Gozal D, and Sánchez-de-la-Torre M
- Subjects
- Adult, Aged, Carcinogenesis, Enzyme-Linked Immunosorbent Assay, Female, Humans, Hypoxia, Intercellular Adhesion Molecule-1 metabolism, Interleukin-8 metabolism, Male, Melanoma complications, Melanoma metabolism, Middle Aged, S100 Calcium Binding Protein beta Subunit metabolism, Skin Neoplasms complications, Skin Neoplasms metabolism, Sleep Apnea, Obstructive complications, Sleep Apnea, Obstructive metabolism, Vascular Cell Adhesion Molecule-1 metabolism, Vascular Endothelial Growth Factor A metabolism, Biomarkers, Tumor metabolism, Melanoma diagnosis, Skin Neoplasms diagnosis, Sleep Apnea, Obstructive diagnosis
- Abstract
The goal of this study was to assess the relationship between the severity of obstructive sleep apnoea (OSA) and the levels of carcinogenesis- and tumour growth-related biomarkers in patients with cutaneous melanoma.This multicentre observational study included patients who were newly diagnosed with melanoma. The patients were classified as non-OSA (apnoea-hypopnoea index (AHI) 0-5 events·h
-1 ), mild OSA (AHI 5-15 events·h-1 ) and moderate-severe OSA (AHI >15 events·h-1 ). ELISAs were performed to analyse the serum levels of hypoxia- and tumour adhesion-related biomarkers (vascular endothelial growth factor (VEGF), interleukin (IL)-8, intracellular adhesion molecule (ICAM) and vascular cell adhesion molecule (VCAM)-1) and markers of tumour aggressiveness (S100 calcium-binding protein B (S100B) and melanoma inhibitory activity (MIA)). A logistic model adjusted for age, sex and body mass index was fitted to each biomarker, and the AHI served as the dependent variable.360 patients were included (52.2% male, median (interquartile range) age 55.5 (43.8-68.0) years and AHI 8.55 (2.8-19.5) events·h-1 ). The levels of VEGF, IL-8, ICAM-1, S100B and MIA were not related to the severity of OSA. The levels of VCAM-1 were higher in patients with OSA than those without OSA (mild OSA: odds ratio (OR) 2.07, p=0.021; moderate-severe OSA: OR 2.35, p=0.013).In patients with cutaneous melanoma, OSA was associated with elevated circulating levels of VCAM-1 that could indicate the contribution of OSA in tumorigenesis via integrin-based adhesion., Competing Interests: Conflict of interest: None declared., (Copyright ©ERS 2018.)- Published
- 2018
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