Search

Introduction: Sublingual allergen specific immunotherapy (SLIT) constitutes a prefered route of administration of AIT for respiraotory allergies, especially in children population. The aim of our study was to investigate sustained efficacy of SLIT in a 4-yeras observational case control study trial, including 2 yeras of follow up after completion of a 2 - yeras period of treatment. Methodes: A case control observational study inculded children with history of mild to moderate allergen induced AR and asthma, inadequately controlled by symptomatic medications. 59 patients completed the trail. End points included nasal and asthma symptom and medication scores. Results: The mean nasal and asthma symptoms was reduced by 75% (x2=37,783, p Conclusions: The results confirm positive clinical outcomes and long lasting effects of SLIT.

Background: Allergen-specific immunotherapy (AIT) holds a great promise in the management of allergic conditions, as the only with the capability to change the natural causes of allergic diseases. Most studies evaluated clinical scores as the main parameters, whereas immunological and-or inflammatory factors were studied only occasionally. The aim of our study was to investigate the efficacy of AIT drops on FeNO as the main non-invasive parameters of eosinophil airway inflammation. We also compared the relation of asthma and medication scores and parameters of lung function. Methods: 59 asthmatic children were included in the study. 34 patients were received AIT drops plus standard pharmacotherapy while 29 children received only standard pharmacotherapy according to the GINA guideline. Efficacy was evaluated using FeNO, asthma and medication symptom score and lung function tests. The results of the test were compared at baseline, during the first year of follow up period and at the end of the observational period. Results: Both asthma and rhinitis scores were decreased during the first year of treatment, with the tendency of further decrease in the second year of follow up period, but only in the experimental group. We observed both significant reduction between FeNO1 and FeNO2 (p