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Your search keyword '"Brenda Kwambana"' showing total 2 results
Start Over Author "Brenda Kwambana" Publisher european respiratory society
2 results on '"Brenda Kwambana"'

1. The impact of long-term azithromycin on antibiotic resistance in HIV-associated chronic lung disease

Author

Regina E. Abotsi, Mark P. Nicol, Grace McHugh, Victoria Simms, Andrea M. Rehman, Charmaine Barthus, Lucky G. Ngwira, Brenda Kwambana-Adams, Robert S. Heyderman, Jon Ø. Odland, Rashida A. Ferrand, and Felix S. Dube

Subjects
Medicine
Abstract

Selection for resistance to azithromycin (AZM) and other antibiotics such as tetracyclines and lincosamides remains a concern with long-term AZM use for treatment of chronic lung diseases (CLD). We investigated the impact of 48 weeks of AZM on the carriage and antibiotic resistance of common respiratory bacteria among children with HIV-associated CLD. Nasopharyngeal (NP) swabs and sputa were collected at baseline, 48 and 72 weeks from participants with HIV-associated CLD randomised to receive weekly AZM or placebo for 48 weeks and followed post-intervention until 72 weeks. The primary outcomes were prevalence and antibiotic resistance of Streptococcus pneumoniae (SP), Staphylococcus aureus (SA), Haemophilus influenzae (HI) and Moraxella catarrhalis (MC) at these timepoints. Mixed-effects logistic regression and Fisher's exact test were used to compare carriage and resistance, respectively. Of 347 (174 AZM, 173 placebo) participants (median age 15 years (IQR 13–18), female 49%), NP carriage was significantly lower in the AZM (n=159) compared to placebo (n=153) arm for SP (18% versus 41%, p

Published
2021
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2. The impact of long-term azithromycin on antibiotic resistance in HIV-associated chronic lung disease

Author

Andrea M. Rehman, Rashida A. Ferrand, Lucky G. Ngwira, Victoria Simms, Mark P. Nicol, Charmaine Barthus, Brenda Kwambana-Adams, Robert S. Heyderman, Regina E. Abotsi, Felix S. Dube, Jon Øyvind Odland, and Grace McHugh

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, biology, medicine.drug_class, business.industry, Antibiotics, wc_503_5, wc_503, Azithromycin, medicine.disease_cause, biology.organism_classification, Placebo, Haemophilus influenzae, qw_45, Moraxella catarrhalis, Antibiotic resistance, Carriage, Internal medicine, Streptococcus pneumoniae, medicine, business, wf_600, medicine.drug
Abstract

Selection for resistance to azithromycin (AZM) and other antibiotics such as tetracyclines and lincosamides remains a concern with long-term AZM use for treatment of chronic lung diseases (CLD). We investigated the impact of 48 weeks of AZM on the carriage and antibiotic resistance of common respiratory bacteria among children with HIV-associated CLD.Nasopharyngeal (NP) swabs and sputa were collected at baseline, 48 and 72 weeks from participants with HIV-associated CLD randomised to receive weekly AZM or placebo for 48 weeks and followed post-intervention until 72 weeks. The primary outcomes were prevalence and antibiotic resistance of Streptococcus pneumoniae (SP), Staphylococcus aureus (SA), Haemophilus influenzae (HI) and Moraxella catarrhalis (MC) at these timepoints. Mixed-effects logistic regression and Fisher's exact test were used to compare carriage and resistance, respectively.Of 347 (174 AZM, 173 placebo) participants (median age 15 years (IQR 13–18), female 49%), NP carriage was significantly lower in the AZM (n=159) compared to placebo (n=153) arm for SP (18% versus 41%, pversus 16%, p=0.01) and MC (4% versus 11%, p=0.02); SP resistance to AZM (62% (18 out of 29) versus 13% (8 out of 63), pversus 21% (13 out of 63), pversus 3% (1 out of 31), pversus 13% (4 out of 31), p=0.05) and clindamycin (79% (27 out of 34) versus 3% (1 out of 31), pThe persistence of antibiotic resistance and its clinical relevance for future infectious episodes requiring treatment needs further investigation.

Published
2022

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