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1. A late sharp increase in influenza detections and low interim vaccine effectiveness against the circulating A(H3N2) strain, Denmark, 2021/22 influenza season up to 25 March 2022.

Author

Emborg HD, Vestergaard LS, Botnen AB, Nielsen J, Krause TG, and Trebbien R

Subjects
Case-Control Studies, Child, Denmark epidemiology, Humans, Influenza A Virus, H3N2 Subtype genetics, Influenza B virus, Seasons, Vaccination, Vaccine Efficacy, COVID-19, Influenza Vaccines, Influenza, Human epidemiology, Influenza, Human prevention & control
Abstract

We estimated interim influenza A vaccine effectiveness (VE) following a late sharp rise in cases during an influenza A(H3N2)-dominated 2021/22 season, after lifting COVID-19 restrictions. In children aged 2-6 years offered a live attenuated influenza vaccine, adjusted VE was 62.7% (95% CI: 10.9-84.4) in hospitalised and 64.2% (95% CI: 50.5-74.1) in non-hospitalised children. In non-hospitalised patients aged 7-44 years, VE was 24.8% (95% CI: 12.8-35.2); VE was non-significant in remaining age groups and hospital/non-hospital settings.

Published
2022
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