1. Ultra-hydrophilic stent platforms promote early vascular healing and minimise late tissue response: a potential alternative to second-generation drug-eluting stents
- Author
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Lynn Bailey, James R. L. Stanley, Algirdas Ziogas, Vincent Milleret, Kumaran Kolandaivelu, Stefano Buzzi, Brett Zani, Gee K. Wong, Arik Zucker, Peter Markham, Martin Ehrbar, Elazer R. Edelman, Ahmed A. Khattab, Deepak L. Bhatt, and Abraham R. Tzafriri
- Subjects
Drug ,medicine.medical_specialty ,Intimal hyperplasia ,Swine ,medicine.medical_treatment ,media_common.quotation_subject ,030204 cardiovascular system & hematology ,Article ,03 medical and health sciences ,Vascular healing ,Percutaneous Coronary Intervention ,0302 clinical medicine ,In vivo ,Neointima ,Internal medicine ,Coronary stent ,medicine ,Animals ,030212 general & internal medicine ,media_common ,business.industry ,digestive, oral, and skin physiology ,Stent ,Thrombosis ,medicine.disease ,Surgery ,Coronary arteries ,Stenosis ,medicine.anatomical_structure ,Cardiology ,Stents ,Rabbits ,Cardiology and Cardiovascular Medicine ,business ,Hydrophobic and Hydrophilic Interactions - Abstract
AIMS: Simple surface modifications can enhance coronary stent performance. Ultra-hydrophilic surface (UHS) treatment of contemporary bare metal stents (BMS) was assessed in vivo to verify whether such stents can provide long-term efficacy comparable to second-generation drug-eluting stents (DES) while promoting healing comparably to BMS. METHODS AND RESULTS: UHS-treated BMS, untreated BMS and corresponding DES were tested for three commercial platforms. A thirty-day and a 90-day porcine coronary model were used to characterise late tissue response. Three-day porcine coronary and seven-day rabbit iliac models were used for early healing assessment. In porcine coronary arteries, hydrophilic treatment reduced intimai hyperplasia relative to the BMS and corresponding DES platforms (1.5-fold to threefold reduction in 30-day angiographic and histological stenosis; p
- Published
- 2017