1. Alterations in sperm long RNA contribute to the epigenetic inheritance of the effects of postnatal trauma
- Author
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Eric A. Miska, Katharina Gapp, Pawel Pelczar, Tanay Ghosh, Grégoire Vernaz, Konrad L. M. Rudolph, Wayo Matsushima, Gretchen van Steenwyk, Francesca Manuella, Isabelle M. Mansuy, Pierre-Luc Germain, Martin Roszkowski, Germain, P. L. [0000-0003-3418-4218], Rudolph, K. L. M. [0000-0002-9866-7051], Vernaz, G. [0000-0001-8942-2370], Mansuy, I. M. [0000-0001-7785-5371], Miska, E. A. [0000-0002-4450-576X], Apollo - University of Cambridge Repository, University of Zurich, Miska, E A, Germain, PL [0000-0003-3418-4218], Rudolph, KLM [0000-0002-9866-7051], Vernaz, G [0000-0001-8942-2370], Mansuy, IM [0000-0001-7785-5371], and Miska, EA [0000-0002-4450-576X]
- Subjects
Epigenomics ,Male ,medicine.medical_specialty ,Small RNA ,Epigenetic inheritance ,long RNA ,Molecular biology ,Physiology ,medicine.medical_treatment ,2804 Cellular and Molecular Neuroscience ,610 Medicine & health ,Biology ,Epigenesis, Genetic ,03 medical and health sciences ,2738 Psychiatry and Mental Health ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Human fertilization ,Internal medicine ,medicine ,1312 Molecular Biology ,Epigenetics ,631/443 ,030304 developmental biology ,45/90 ,45/91 ,0303 health sciences ,10242 Brain Research Institute ,Insulin ,article ,RNA ,Embryo ,DNA Methylation ,Sperm ,Spermatozoa ,Psychiatry and Mental health ,Endocrinology ,570 Life sciences ,biology ,64/60 ,631/378 ,Developmental biology ,030217 neurology & neurosurgery ,631/337 ,Neuroscience - Abstract
Psychiatric diseases have a strong heritable component known to not be restricted to DNA sequence-based genetic inheritance alone but to also involve epigenetic factors in germ cells. Initial evidence suggested that sperm RNA is causally linked to the transmission of symptoms induced by traumatic experiences. Here, we show that alterations in long RNA in sperm contribute to the inheritance of specific trauma symptoms. Injection of long RNA fraction from sperm of males exposed to postnatal trauma recapitulates the effects on food intake, glucose response to insulin and risk-taking in adulthood whereas the small RNA fraction alters body weight and behavioural despair. Alterations in long RNA are maintained after fertilization, suggesting a direct link between sperm and embryo RNA., Molecular Psychiatry, 25, ISSN:1359-4184, ISSN:1476-5578
- Published
- 2020
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