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Your search keyword '"Sorana Morrissy"' showing total 2 results
Start Over Author "Sorana Morrissy" Publisher escholarship, university of california
2 results on '"Sorana Morrissy"'

1. Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse

Author

Jiao Zhang, Andrew S. Potter, W. Clay Gustafson, Liguo Zhang, Feng Zhang, Scott L. Pomeroy, Maryam Fouladi, Martine F. Roussel, Allison Pribnow, Xuezhao Liu, Michael D. Taylor, Kalen P. Berry, Q. Richard Lu, Lingli Xu, Blaise V. Jones, Christine Fuller, Maria C. Vladoiu, James M. Olson, Emily J. Girard, Weidong Tian, Marc Remke, Tao Zheng, S. Steven Potter, Xuelian He, Mei Xin, Wenhao Zhou, A. Sorana Morrissy, Rachid Drissi, Zaili Luo, Stephanie M.C. Smith, William A. Weiss, L. Frank Huang, and Zeng-Jie Yang

Subjects
0301 basic medicine, Male, Cancer Research, Datasets as Topic, Tumor initiation, medicine.disease_cause, Cell Transformation, Transgenic, Transcriptome, Mice, 0302 clinical medicine, Stem Cell Research - Nonembryonic - Human, 2.1 Biological and endogenous factors, Gene Regulatory Networks, RNA-Seq, Sonic hedgehog, Aetiology, Child, Cancer, Pediatric, Tumor, Brain Neoplasms, AURORA-A/MYCN, OPC-like, Prognosis, HIPPO-YAP/TAZ, glial progenitors, Gene Expression Regulation, Neoplastic, Cell Transformation, Neoplastic, Oncology, Local, progenitor heterogeneity, 030220 oncology & carcinogenesis, Child, Preschool, Gene Knockdown Techniques, Neoplastic Stem Cells, Female, Stem Cell Research - Nonembryonic - Non-Human, Single-Cell Analysis, Neuroglia, Signal Transduction, Biotechnology, OLIG2, Oncology and Carcinogenesis, Mice, Transgenic, Biology, Cell Line, 03 medical and health sciences, Rare Diseases, Cell Line, Tumor, medicine, Genetics, Animals, Humans, Hedgehog Proteins, recurrent tumors, Oncology & Carcinogenesis, Progenitor cell, Preschool, Progenitor, Cell Proliferation, Medulloblastoma, Neoplastic, Animal, medulloblastomas, Human Genome, Neurosciences, Oligodendrocyte Transcription Factor 2, medicine.disease, Stem Cell Research, Survival Analysis, Brain Disorders, Brain Cancer, Disease Models, Animal, 030104 developmental biology, Neoplasm Recurrence, Gene Expression Regulation, Disease Models, Cancer research, biology.protein, sonic hedgehog (SHH) signaling, Neoplasm Recurrence, Local, Carcinogenesis, single-cell transcriptomics
Abstract

Progenitor heterogeneity and identities underlying tumor initiation and relapse in medulloblastomas remain elusive. Utilizing single-cell transcriptomic analysis, we demonstrated a developmental hierarchy of progenitor pools in Sonic Hedgehog (SHH) medulloblastomas, and identified OLIG2-expressing glial progenitors as transit-amplifying cells at the tumorigenic onset. Although OLIG2+ progenitors become quiescent stem-like cells in full-blown tumors, they are highly enriched in therapy-resistant and recurrent medulloblastomas. Depletion of mitotic Olig2+ progenitors or Olig2 ablation impeded tumor initiation. Genomic profiling revealed that OLIG2 modulates chromatin landscapes and activates oncogenic networks including HIPPO-YAP/TAZ and AURORA-A/MYCN pathways. Co-targeting these oncogenic pathways induced tumor growth arrest. Together, our results indicate that glial lineage-associated OLIG2+ progenitors are tumor-initiating cells during medulloblastoma tumorigenesis and relapse, suggesting OLIG2-driven oncogenic networks as potential therapeutic targets.

Published
2019

2. Subgroup-specific structural variation across 1,000 medulloblastoma genomes

Author

Northcott, PA, Shih, DJH, Peacock, J, Garzia, L, Sorana Morrissy, A, Zichner, T, Stútz, AM, Korshunov, A, Reimand, J, Schumacher, SE, Beroukhim, R, Ellison, DW, Marshall, CR, Lionel, AC, MacK, S, Dubuc, A, Yao, Y, Ramaswamy, V, Luu, B, Rolider, A, Cavalli, FMG, Wang, X, Remke, M, Wu, X, Chiu, RYB, Chu, A, Chuah, E, Corbett, RD, Hoad, GR, Jackman, SD, Li, Y, Lo, A, Mungall, KL, Ming Nip, K, Qian, JQ, Raymond, AGJ, Thiessen, N, Varhol, RJ, Birol, I, Moore, RA, Mungall, AJ, Holt, R, Kawauchi, D, Roussel, MF, Kool, M, Jones, DTW, Witt, H, Fernandez-L, A, Kenney, AM, Wechsler-Reya, RJ, Dirks, P, Aviv, T, Grajkowska, WA, Perek-Polnik, M, Haberler, CC, Delattre, O, Reynaud, SS, Doz, FF, Pernet-Fattet, SS, Cho, BK, Kim, SK, Wang, KC, Scheurlen, W, Eberhart, CG, Fèvre-Montange, M, Jouvet, A, Pollack, IF, Fan, X, Muraszko, KM, Yancey Gillespie, G, Di Rocco, C, Massimi, L, Michiels, EMC, Kloosterhof, NK, French, PJ, Kros, JM, Olson, JM, Ellenbogen, RG, Zitterbart, K, Kren, L, Thompson, RC, and Cooper, MK

Subjects
Oncogene Proteins, Fusion, DNA Copy Number Variations, Genome, Human, General Science & Technology, NF-kappa B, Genes, myc, Proteins, Nerve Tissue Proteins, Genomics, Translocation, Genetic, Transforming Growth Factor beta, Gene Duplication, Genomic Structural Variation, MD Multidisciplinary, Humans, Hedgehog Proteins, RNA, Long Noncoding, Cerebellar Neoplasms, Carrier Proteins, Child, Medulloblastoma, Signal Transduction
Abstract

Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive chemotherapy. As medulloblastoma exhibits marked intertumoural heterogeneity, with at least four distinct molecular variants, previous attempts to identify targets for therapy have been underpowered because of small samples sizes. Here we report somatic copy number aberrations (SCNAs) in 1,087 unique medulloblastomas. SCNAs are common in medulloblastoma, and are predominantly subgroup-enriched. The most common region of focal copy number gain is a tandem duplication of SNCAIP, a gene associated with Parkinson's disease, which is exquisitely restricted to Group 4α. Recurrent translocations of PVT1, including PVT1-MYC and PVT1-NDRG1, that arise through chromothripsis are restricted to Group 3. Numerous targetable SCNAs, including recurrent events targeting TGF-β signalling in Group 3, and NF-κB signalling in Group 4, suggest future avenues for rational, targeted therapy. © 2012 Macmillan Publishers Limited. All rights reserved.

Published
2012
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