1. MRI-assessed locus coeruleus integrity is heritable and associated with multiple cognitive domains, mild cognitive impairment, and daytime dysfunction
- Author
-
Jeremy A. Elman, Linda K. McEvoy, Sean N. Hatton, Christine Fennema-Notestine, Matthew S. Panizzon, Hong Xian, Carol E. Franz, McKenna E. Williams, Daniel E. Gustavson, William S. Kremen, Michael J. Lyons, Ruth E. McKenzie, Chandra A. Reynolds, Donald J. Hagler, Michael C. Neale, Rosemary Toomey, Latonya K. Cross, Nathan A. Gillespie, Mark Sanderson-Cimino, Mark W. Logue, Lisa T. Eyler, Nathan Whitsel, Anders M. Dale, Xin M. Tu, Richard L. Hauger, Olivia K. Puckett, Graham M L Eglit, Eric Granholm, Asad Beck, and Amy J. Jak
- Subjects
Male ,Aging ,Epidemiology ,Neurodegenerative ,Neuropsychological Tests ,heritability ,0302 clinical medicine ,Cognition ,Verbal fluency test ,2.1 Biological and endogenous factors ,sleep-wake disturbance ,Aetiology ,Cognitive impairment ,Episodic memory ,0303 health sciences ,Health Policy ,Alzheimer's disease ,Magnetic Resonance Imaging ,Psychiatry and Mental health ,Disease Progression ,Psychology ,Sleep Research ,sleep–wake disturbance ,Clinical psychology ,Clinical Sciences ,Basic Behavioral and Social Science ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,mild cognitive impairment ,Developmental Neuroscience ,Behavioral and Social Science ,Acquired Cognitive Impairment ,Humans ,Cognitive Dysfunction ,030304 developmental biology ,Aged ,Memory Disorders ,Featured Articles ,locus coeruleus ,Prevention ,neuromelanin magnetic resonance imaging ,Neurosciences ,Structural integrity ,Semantic fluency ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Featured Article ,Brain Disorders ,Geriatrics ,Locus coeruleus ,Dementia ,Neurology (clinical) ,Geriatrics and Gerontology ,Sleep ,030217 neurology & neurosurgery - Abstract
Author(s): Elman, Jeremy A; Puckett, Olivia K; Beck, Asad; Fennema-Notestine, Christine; Cross, Latonya K; Dale, Anders M; Eglit, Graham ML; Eyler, Lisa T; Gillespie, Nathan A; Granholm, Eric L; Gustavson, Daniel E; Hagler, Donald J; Hatton, Sean N; Hauger, Richard; Jak, Amy J; Logue, Mark W; McEvoy, Linda K; McKenzie, Ruth E; Neale, Michael C; Panizzon, Matthew S; Reynolds, Chandra A; Sanderson-Cimino, Mark; Toomey, Rosemary; Tu, Xin M; Whitsel, Nathan; Williams, McKenna E; Xian, Hong; Lyons, Michael J; Franz, Carol E; Kremen, William S | Abstract: IntroductionThe locus coeruleus (LC) undergoes extensive neurodegeneration in early Alzheimer's disease (AD). The LC is implicated in regulating the sleep-wake cycle, modulating cognitive function, and AD progression.MethodsParticipants were 481 men (ages 62 to 71.7) from the Vietnam Era Twin Study of Aging. LC structural integrity was indexed by neuromelanin-sensitive magnetic resonance imaging (MRI) contrast-to-noise ratio (LCCNR ). We examined LCCNR , cognition, amnestic mild cognitive impairment (aMCI), and daytime dysfunction.ResultsHeritability of LCCNR was .48. Participants with aMCI showed greater daytime dysfunction. Lower LCCNR was associated with poorer episodic memory, general verbal fluency, semantic fluency, and processing speed, as well as increased odds of aMCI and greater daytime dysfunction.DiscussionReduced LC integrity is associated with widespread differences across cognitive domains, daytime sleep-related dysfunction, and risk for aMCI. These findings in late-middle-aged adults highlight the potential of MRI-based measures of LC integrity in early identification of AD risk.
- Published
- 2021