1. Comparison of total body irradiation versus non-total body irradiation containing regimens for de novo acute myeloid leukemia in children
- Author
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Dandoy, Christopher E, Davies, Stella M, Ahn, Kwang Woo, He, Yizeng, Kolb, Anders E, Levine, John, Bo-Subait, Stephanie, Abdel-Azim, Hisham, Bhatt, Neel, Chewing, Joseph, Gadalla, Shahinaz, Gloude, Nicholas, Hayashi, Robert, Lalefar, Nahal R, Law, Jason, MacMillan, Margaret, O’Brien, Tracy, Prestidge, Timothy, Sharma, Akshay, Shaw, Peter, Winestone, Lena, and Eapen, Mary
- Subjects
Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Hematology ,Traumatic Brain Injury (TBI) ,Traumatic Head and Spine Injury ,Physical Injury - Accidents and Adverse Effects ,Brain Disorders ,Transplantation ,Rare Diseases ,Pediatric ,Cancer ,Busulfan ,Child ,Cyclophosphamide ,Graft vs Host Disease ,Hematopoietic Stem Cell Transplantation ,Humans ,Leukemia ,Myeloid ,Acute ,Retrospective Studies ,Transplantation Conditioning ,Whole-Body Irradiation ,Cardiorespiratory Medicine and Haematology ,Immunology ,Cardiovascular medicine and haematology - Abstract
With limited data comparing hematopoietic cell transplant outcomes between myeloablative total body irradiation (TBI) containing and non-TBI regimens in children with de novo acute myeloid leukemia, the aim of this study was to compare transplant-outcomes between these regimens. Cox regression models were used to compare transplant-outcomes after TBI and non-TBI regimens in 624 children transplanted between 2008 and 2016. Thirty two percent (n=199) received TBI regimens whereas 68% (n=425) received non-TBI regimens. Five-year non-relapse mortality was higher with TBI regimens (22% vs. 11%, p
- Published
- 2021