1. Glycocalyx Remodeling with Glycopolymer-Based Proteoglycan Mimetics
- Author
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Huang, Mia L, Smith, Raymond AA, Trieger, Greg W, and Godula, Kamil
- Subjects
Biochemistry and Cell Biology ,Biological Sciences ,Stem Cell Research ,Regenerative Medicine ,Biotechnology ,Animals ,Biomimetic Materials ,Glycocalyx ,Glycoconjugates ,Mice ,Polymers ,Proteoglycans ,Stem Cells ,Glycan microarrays ,Glycopolymers ,Glycosaminoglycans ,Stem cells ,Stem cell differentiation ,Stem cell s ,Other Chemical Sciences ,Developmental Biology ,Biochemistry and cell biology ,Medicinal and biomolecular chemistry - Abstract
The cellular glycocalyx controls many of the crucial signaling pathways involved in cellular development. Synthetic materials that can mimic the multivalency and three-dimensional architecture of native glycans serve as important tools for deciphering and exploiting the roles of these glycans. Here we describe a chemical approach for the engineering of growth-factor interactions at the surfaces of stem cells using synthetic glycomimetic materials, with an eye towards promoting their commitment towards specific cell lineages with therapeutic potential.
- Published
- 2016