1. In-hospital mortality and severe outcomes after hospital discharge due to COVID-19: A prospective multicenter study from Brazil.
- Author
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Perazzo, Hugo, Cardoso, Sandra W, Ribeiro, Maria Pia D, Moreira, Rodrigo, Coelho, Lara E, Jalil, Emilia M, Japiassú, André Miguel, Gouvêa, Elias Pimentel, Nunes, Estevão Portela, Andrade, Hugo Boechat, Gouvêa, Luciano Barros, Ferreira, Marcel Treptow, Rodrigues, Pedro Mendes de Azambuja, Moreira, Ronaldo, Geraldo, Kim, Freitas, Lucilene, Pacheco, Vinicius V, João, Esau Custódio, Fuller, Trevon, Rocha, Verônica Diniz, Nunes, Ceuci de Lima Xavier, Souza, Tâmara Newman Lobato, Toscano, Ana Luiza Castro Conde, Schwarzbold, Alexandre Vargas, Noal, Helena Carolina, Pinto, Gustavo de Araujo, Lemos, Paula Macedo de Oliveira, Santos, Carla, Mello, Fernanda Carvalho de Queiroz, Veloso, Valdilea G, Grinsztejn, Beatriz, and RECOVER-SUS Brasil Group
- Subjects
RECOVER-SUS Brasil Group ,ALT ,alanine aminotransferase ,AST ,aspartate aminotransferase BMI ,body mass index ,CI ,confidence interval ,COVID-19 ,COVID-19 ,Coronavirus disease 2019 ,CRP ,C-reactive protein ,ESR ,erythrocyte sedimentation rate ,ICU ,intensive care unit ,INR ,international normalized ratio ,IQR ,interquartile range ,In-hospital mortality ,NIV ,non-invasive ventilation ,PD ,person-days ,PY ,person-years ,Post-COVID-19 ,REDCap ,research electronic data capture ,SAPS-III ,simplified acute physiology score III ,SARS-CoV-2 ,severe acute respiratory syndrome coronavirus 2 ,SOFA ,sequential organ failure assessment ,VIF ,variance inflation factor ,VOC ,variant of concern ,WHO ,World Health Organization ,aHR ,adjusted-hazard ratio ,Clinical Research ,Good Health and Well Being - Abstract
BackgroundWe evaluated in-hospital mortality and outcomes incidence after hospital discharge due to COVID-19 in a Brazilian multicenter cohort.MethodsThis prospective multicenter study (RECOVER-SUS, NCT04807699) included COVID-19 patients hospitalized in public tertiary hospitals in Brazil from June 2020 to March 2021. Clinical assessment and blood samples were performed at hospital admission, with post-hospital discharge remote visits. Hospitalized participants were followed-up until March 31, 2021. The outcomes were in-hospital mortality and incidence of rehospitalization or death after hospital discharge. Kaplan-Meier curves and Cox proportional-hazard models were performed.Findings1589 participants [54.5% male, age=62 (IQR 50-70) years; BMI=28.4 (IQR,24.9-32.9) Kg/m² and 51.9% with diabetes] were included. A total of 429 individuals [27.0% (95%CI,24.8-29.2)] died during hospitalization (median time 14 (IQR,9-24) days). Older age [vs
- Published
- 2022