1. A Case of S-Variant Hepatitis B Virus: An Immune System Escape Artist
- Author
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Shah, Amar S, Civelli, Valerie F, Bali, Varun, Johnson, Royce H, and Heidari, Arash
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Immunology ,Digestive Diseases ,Hepatitis ,HIV/AIDS ,Vaccine Related ,Liver Disease ,Hepatitis - B ,Chronic Liver Disease and Cirrhosis ,Infectious Diseases ,Aetiology ,2.1 Biological and endogenous factors ,Inflammatory and immune system ,Infection ,Good Health and Well Being ,Genetic Variation ,Hepatitis B ,Hepatitis B Surface Antigens ,Hepatitis B virus ,Humans ,Immune System ,Male ,Middle Aged ,S-variant hepatitis B ,hepatitis B viral infection ,HBV ,preS/S mutant HBV ,immune escape HBV - Abstract
Genomic variants of the hepatitis B virus (HBV) preS/S protein are well-known to occur. Typically, immunity is gained through recovered HBV infection or by immunization. Very rarely, there are certain mutations that may enable HBV escape from the immune detection. PreS/S mutants may present with unpredictable pathobiologic, clinical, and transmittable implications. Standard laboratory testing for genomic HBV variants is not routinely performed by reference guidelines. s-variant HBV management remains challenging. Herein is a case of s-variant chronic HBV infection in a 55-year-old man. Diagnosis and treatment are described.
- Published
- 2021