1. Height in pre- and postmenopausal women is influenced by estrogen receptor alpha gene polymorphisms
- Author
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Albert Hofman, Arjan P. Bergink, Marjolein van der Klift, Geraline Leusink, Yue Fang, Joyce B. J. van Meurs, Stephanie C. E. Schuit, Johannes P.T.M. van Leeuwen, André G. Uitterlinden, Huibert A. P. Pols, Internal Medicine, and Epidemiology
- Subjects
Male ,Candidate gene ,medicine.medical_specialty ,Bone density ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,Population ,Estrogen receptor ,Minisatellite Repeats ,Biology ,Biochemistry ,Linkage Disequilibrium ,Body Mass Index ,Rotterdam Study ,Endocrinology ,Bone Density ,Internal medicine ,medicine ,Humans ,Allele ,education ,Deoxyribonucleases, Type II Site-Specific ,Alleles ,Osteoporosis, Postmenopausal ,Aged ,Aged, 80 and over ,Menarche ,education.field_of_study ,Lumbar Vertebrae ,Polymorphism, Genetic ,Biochemistry (medical) ,Haplotype ,Age Factors ,Estrogen Receptor alpha ,Middle Aged ,Body Height ,Postmenopause ,Haplotypes ,Premenopause ,Receptors, Estrogen ,Female ,Estrogen receptor alpha ,Polymorphism, Restriction Fragment Length - Abstract
The estrogen receptor alpha gene (ESR1) is known to be involved in metabolic pathways influencing growth. We have performed two population-based association studies using three common polymorphisms within this candidate gene to determine whether these are associated with variation in adult stature. In 607 women, aged 55-80 yr, from the Rotterdam Study, the ESR1 PvuII-XbaI haplotype 1 (px) and the L allele of the TA repeat polymorphism (
- Published
- 2004