1. The effects of vitamin D supplementation during infancy on growth during the first 2 years of life
- Author
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Eero Kajantie, Sture Andersson, Saara Valkama, Helena Hauta-alus, Jenni Rosendahl, Maria Enlund-Cerullo, Outi Mäkitie, Elisa Holmlund-Suila, Research Programs Unit, HUS Children and Adolescents, Children's Hospital, University of Helsinki, Helsinki University Hospital Area, CAMM - Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, Clinicum, Lastentautien yksikkö, HUSLAB, and Medicum
- Subjects
Male ,25-HYDROXYVITAMIN D ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,Physiology ,Biochemistry ,chemistry.chemical_compound ,0302 clinical medicine ,Endocrinology ,Child Development ,Medicine ,Body Size ,vitamin D supplementation ,030212 general & internal medicine ,CORD BLOOD ,Vitamin D ,Finland ,POPULATION ,Cholecalciferol ,education.field_of_study ,clinical trial ,ASSOCIATION ,25-hydroxyvitamin D ,PREGNANCY ,Quartile ,Child, Preschool ,Prenatal Exposure Delayed Effects ,Female ,ADIPOSITY ,HEALTH ,Vitamin ,Adult ,medicine.medical_specialty ,Offspring ,Population ,CHILDHOOD GROWTH ,030209 endocrinology & metabolism ,Context (language use) ,03 medical and health sciences ,Double-Blind Method ,early childhood growth ,Internal medicine ,Vitamin D and neurology ,Humans ,education ,Pregnancy ,business.industry ,Biochemistry (medical) ,Body Weight ,Infant, Newborn ,Anthropometry ,medicine.disease ,Vitamin D Deficiency ,PREVENTION ,infant ,maternal ,chemistry ,3121 General medicine, internal medicine and other clinical medicine ,Dietary Supplements ,business ,FOLLOW-UP - Abstract
Context The relationship between maternal and infant vitamin D and early childhood growth remains inadequately understood. Objective This work aimed to investigate how maternal and child 25-hydroxyvitamin D (25[OH]D) and vitamin D supplementation affect growth during the first 2 years of life. Methods A randomized, double-blinded, single-center intervention study was conducted from pregnancy until offspring age 2 years. Altogether 812 term-born children with complete data were recruited at a maternity hospital. Children received daily vitamin D3 supplementation of 10 μg (group 10) or 30 μg (group 30) from age 2 weeks to 2 years. Anthropometry and growth rate were measured at age 1 and 2 years. Results Toddlers born to mothers with pregnancy 25(OH)D greater than 125 nmol/L were at 2 years lighter and thinner than the reference group with 25(OH)D of 50 to 74.9 nmol/L (P .053), but group 30 had slower growth in length and head circumference between 6 months and 1 year (P 121 nmol/L) were shorter (mean difference 0.2 SD score [SDS], P = .021), lighter (mean difference 0.4 SDS, P = .001), and thinner (in length-adjusted weight) (mean difference 0.4 SDS, P = .003) compared with the lowest quartile ( Conclusion Vitamin D and early childhood growth may have an inverse U-shaped relationship.
- Published
- 2021