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The article discusses the challenges and complexities of hemoglobin A1c (HbA1c) testing, particularly in patients with abnormal hemoglobin due to hemoglobinopathies. Topics include the importance of choosing appropriate HbA1c testing methodologies, highlights the impact of hemoglobin variants, and suggests strategies for laboratories to mitigate the risk of incorrect results in diabetes diagnosis.

The article focuses on the use of automated systems to detect hemoglobinopathies and thalassemias. It provides a brief overview of the nature and characteristics of the two genetically distinct hemoglobin abnormalities and reviews several automated methods employed to determine their existence. It also suggests the advantage of combining capillary electrophoresis (CE) and high -performance liquid chromatography (HPLC) methods to effectively detect and diagnose such disorders.

The article focuses on the method use for the detection of hemoglobinopathy and thalassemia. It states the two types of disorders that affects hemoglobin (HB) chains such as the qualititave and quantitative disorders. It says that the thalassemias refer as quantitative disorders affecting the rate of normal HB synthesis. It mentions that the electrophoresis method is used in hematological laboratories for the detection of hemoglobinopathies and thalassemias.

An interview with the technical director for the Southeast Business of Quest Diagnostics, Thomas E. Burgess, is presented. When asked about hemoglobinopathy, he replied that it is a hematologic disorder, which is caused due to the alteration in the molecular structure of hemoglobin. He commented that many laboratories are screening with either high performance liquid chromatography (HPLC) or capillary zone electrophoresis (CZE).

The article offers information on the utilization for automated High Performance Liquid Chromatography (HPLC) necessary for identification of hemoglobinopathies.