1. The effects of vitamin D and omega-3 co-supplementation on lipid profile in adults: a systematic review and meta-analysis.
- Author
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Zamani, Mohammad, Sohrabi, Zahra, Aghakhani, Ladan, Leilami, Kimia, Nosratabadi, Saeed, Namkhah, Zahra, Clark, Cain, Haghighat, Neda, Asbaghi, Omid, and Fathi, Fatemeh
- Subjects
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VITAMIN D , *VITAMIN D receptors , *RANDOM effects model , *HIGH density lipoproteins , *LIPIDS , *SCIENCE databases , *WEB databases - Abstract
Purpose: Previous research indicates that vitamin D and omega-3 co-supplementation may benefit overall health, but current evidence regarding its effects on lipid profile remains unclear. The present systematic review and meta-analysis aimed to examine the effects of vitamin D and omega-3 co-supplementation on lipid profile (total cholesterol [TC], low-density lipoprotein [LDL], triglyceride [TG] and high-density lipoprotein [HDL]) in adults. Design/methodology/approach: In this systematic review and meta-analysis, relevant studies were obtained by searching the PubMed, Scopus and Web of Science databases (from inception to January 2022). Weighted mean differences and 95% confidence intervals were estimated via a random-effects model. Heterogeneity, sensitivity analysis and publication bias were reported using standard methods. Findings: Pooled analysis of six randomized controlled trials (RCTs) revealed that vitamin D and omega-3 co-supplementation yielded significant reductions in TG (p = 0.631). A pooled analysis of five trials indicated a significant association between omega-3 and vitamin D treatment and reductions in TC (p = 0.001) and LDL (p = 0.001). Although, pooled analyses of omega-3 and vitamin D did not significantly affect HDL. Originality/value: The findings suggest that vitamin D and omega-3 co-supplementation lowers TG, TC and LDL in adults. Future, large-scale, RCTs on various populations are needed to elucidate further beneficial effects of vitamin D and omega-3 co-supplementation on lipid profile and establish guidelines for clinical practice. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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