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4 results on '"Huebner, Antje K"'

1. Role of FAM134 paralogues in endoplasmic reticulum remodeling, ER‐phagy, and Collagen quality control

Author

Reggio, Alessio, primary, Buonomo, Viviana, additional, Berkane, Rayene, additional, Bhaskara, Ramachandra M, additional, Tellechea, Mariana, additional, Peluso, Ivana, additional, Polishchuk, Elena, additional, Di Lorenzo, Giorgia, additional, Cirillo, Carmine, additional, Esposito, Marianna, additional, Hussain, Adeela, additional, Huebner, Antje K, additional, Hübner, Christian A, additional, Settembre, Carmine, additional, Hummer, Gerhard, additional, Grumati, Paolo, additional, and Stolz, Alexandra, additional

Published
2021
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2. MiT/ TFE factors control ER ‐phagy via transcriptional regulation of FAM 134B

Author

Cinque, Laura, primary, Leonibus, Chiara, additional, Iavazzo, Maria, additional, Krahmer, Natalie, additional, Intartaglia, Daniela, additional, Salierno, Francesco Giuseppe, additional, De Cegli, Rossella, additional, Di Malta, Chiara, additional, Svelto, Maria, additional, Lanzara, Carmela, additional, Maddaluno, Marianna, additional, Wanderlingh, Luca Giorgio, additional, Huebner, Antje K, additional, Cesana, Marcella, additional, Bonn, Florian, additional, Polishchuk, Elena, additional, Hübner, Christian A, additional, Conte, Ivan, additional, Dikic, Ivan, additional, Mann, Matthias, additional, Ballabio, Andrea, additional, Sacco, Francesca, additional, Grumati, Paolo, additional, and Settembre, Carmine, additional

Published
2020
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3. A mouse model for distal renal tubular acidosis reveals a previously unrecognized role of the V‐ATPase a4 subunit in the proximal tubule

Author

Hennings, J. Christopher, primary, Picard, Nicolas, additional, Huebner, Antje K., additional, Stauber, Tobias, additional, Maier, Hannes, additional, Brown, Dennis, additional, Jentsch, Thomas J., additional, Vargas‐Poussou, Rosa, additional, Eladari, Dominique, additional, and Hübner, Christian A., additional

Published
2012
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4. MiT/ <scp>TFE</scp> factors control <scp>ER</scp> ‐phagy via transcriptional regulation of <scp>FAM</scp> 134B

Author

Marianna Maddaluno, Carmela Lanzara, Paolo Grumati, Ivan Conte, Christian A. Hübner, Chiara Di Malta, Maria Iavazzo, Antje K. Huebner, Daniela Intartaglia, Carmine Settembre, Francesco Giuseppe Salierno, Chiara De Leonibus, Florian Bonn, Maria Svelto, Rossella De Cegli, Matthias Mann, Ivan Dikic, Luca Giorgio Wanderlingh, Laura Cinque, Francesca Sacco, Elena Polishchuk, Andrea Ballabio, Marcella Cesana, Natalie Krahmer, Cinque, Laura, De Leonibus, Chiara, Iavazzo, Maria, Krahmer, Natalie, Intartaglia, Daniela, Salierno, Francesco Giuseppe, De Cegli, Rossella, Di Malta, Chiara, Svelto, Maria, Lanzara, Carmela, Maddaluno, Marianna, Wanderlingh, Luca Giorgio, Huebner, Antje K, Cesana, Marcella, Bonn, Florian, Polishchuk, Elena, Hübner, Christian A, Conte, Ivan, Dikic, Ivan, Mann, Matthia, Ballabio, Andrea, Sacco, Francesca, Grumati, Paolo, and Settembre, Carmine

Subjects
MECHANISM, ER-phagy, IRS1, ENDOPLASMIC-RETICULUM, Regulator, Biology, Fibroblast growth factor, Chromatin, Epigenetics, Genomics & Functional Genomics, Article, General Biochemistry, Genetics and Molecular Biology, FGF signaling, 03 medical and health sciences, 0302 clinical medicine, Transcriptional regulation, FGF, Fam134B, NETWORK, ER‐phagy, FGFsignaling, Musculoskeletal System, Molecular Biology, Transcription factor, PI3K signaling, 030304 developmental biology, TFEB, 0303 health sciences, RECEPTOR, Settore BIO/18, General Immunology and Microbiology, IRS1/PI3K signaling, General Neuroscience, Endoplasmic reticulum, Autophagy, Er-phagy, Fam134b, Fgfsignaling, Irs1, Pi3k Signaling, Tfeb, Articles, BONE-GROWTH, Cell biology, TEX264, Autophagy & Cell Death, AUTOPHAGY, Signal transduction, 030217 neurology & neurosurgery
Abstract

Lysosomal degradation of the endoplasmic reticulum (ER) via autophagy (ER‐phagy) is emerging as a critical regulator of cell homeostasis and function. The recent identification of ER‐phagy receptors has shed light on the molecular mechanisms underlining this process. However, the signaling pathways regulating ER‐phagy in response to cellular needs are still largely unknown. We found that the nutrient responsive transcription factors TFEB and TFE3—master regulators of lysosomal biogenesis and autophagy—control ER‐phagy by inducing the expression of the ER‐phagy receptor FAM134B. The TFEB/TFE3‐FAM134B axis promotes ER‐phagy activation upon prolonged starvation. In addition, this pathway is activated in chondrocytes by FGF signaling, a critical regulator of skeletal growth. FGF signaling induces JNK‐dependent proteasomal degradation of the insulin receptor substrate 1 (IRS1), which in turn inhibits the PI3K‐PKB/Akt‐mTORC1 pathway and promotes TFEB/TFE3 nuclear translocation and enhances FAM134B transcription. Notably, FAM134B is required for protein secretion in chondrocytes, and cartilage growth and bone mineralization in medaka fish. This study identifies a new signaling pathway that allows ER‐phagy to respond to both metabolic and developmental cues., Nuclear translocation of TFEB/TFE3 transcription factors and expression of FAM134B downstream of FGF18 signalling induce ER‐phagy in chondrocytes to promote bone development.

Published
2020

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