1. [Hypoglycaemic coma revealing a malignant recurrence during Doege-Potter syndrome].
- Author
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Le Coustumier EM, Vandeix E, Delage-Corre M, Bertin F, and Melloni B
- Subjects
- Aged, 80 and over, Biopsy, Disease Progression, Dyspnea etiology, Fatal Outcome, Humans, Male, Pleural Neoplasms pathology, Pleural Neoplasms radiotherapy, Pleural Neoplasms surgery, Sarcoma pathology, Sarcoma radiotherapy, Solitary Fibrous Tumor, Pleural pathology, Solitary Fibrous Tumor, Pleural surgery, Thoracic Surgery, Video-Assisted, Coma etiology, Hypoglycemia etiology, Insulin-Like Growth Factor II metabolism, Neoplasm Recurrence, Local metabolism, Paraneoplastic Syndromes etiology, Pleural Neoplasms metabolism, Sarcoma metabolism
- Abstract
Introduction: The Doege-Potter syndrome is a rare paraneoplastic syndrome, first described by Doege and Potter in 1930, that usually involves solid fibrous pleural tumours. Hypoglycaemia is a rare complication of these tumours, due to secretion of insulin-like growth factors, and it can be the presenting symptom. The incidence of malignancy is low, about 12-15 %., Case Report: An 81-year-old Caucasian man, operated on 20 years previously for a benign pleural fibroma, presented with several episodes of loss of consciousness due to profound hypoglycaemia and a history of increasing dyspnea. The chest X-ray revealed an intrathoracic mass. Following excision histological examination confirmed recurrence with malignant transformation to a high-grade sarcoma., Conclusion: The Doege-Potter syndrome is a rare condition but it should be suspected in episodes of hypoglycaemia associated with a history of dyspnea. These patients should be followed up postoperatively because of the risk of tumour recurrence., (Copyright © 2014. Published by Elsevier Masson SAS.)
- Published
- 2015
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