1. Expression of c-Fos protein in the brain after intravenous injection of ghrelin in rats.
- Author
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Takayama K, Johno Y, Hayashi K, Yakabi K, Tanaka T, and Ro S
- Subjects
- Animals, Arcuate Nucleus of Hypothalamus drug effects, Arcuate Nucleus of Hypothalamus metabolism, Area Postrema drug effects, Area Postrema metabolism, Biomarkers metabolism, Brain anatomy & histology, Brain drug effects, Cell Count, Dose-Response Relationship, Drug, Feeding Behavior drug effects, Feeding Behavior physiology, Gastric Mucosa innervation, Ghrelin, Immunohistochemistry, Injections, Intravenous, Male, Neurons drug effects, Peptide Hormones pharmacology, Proto-Oncogene Proteins c-fos drug effects, Rats, Rats, Wistar, Solitary Nucleus drug effects, Solitary Nucleus metabolism, Subfornical Organ drug effects, Subfornical Organ metabolism, Vagus Nerve drug effects, Vagus Nerve metabolism, Brain metabolism, Gastric Acid metabolism, Gastric Mucosa metabolism, Neurons metabolism, Peptide Hormones metabolism, Proto-Oncogene Proteins c-fos metabolism
- Abstract
In this study, we surveyed central neurons that might be activated after peripheral administration of a gut-brain peptide ghrelin, by examining neurons expressing c-Fos protein. First, we examined the relationship between the dose of ghrelin and the amount of gastric acid secreted. Ghrelin induced a significant increase in the amount of gastric acid secretion in a dose-dependent manner. Secondly, we examined central neurons that expressed c-Fos protein after intravenous injection of ghrelin. We found that intravenously injected ghrelin induced the neural expression of c-Fos protein in several nuclei and circumventricular organs in the brain. These results suggest that ghrelin released into the circulation may stimulate central neurons that have some role in the control mechanism for gastric acid secretion.
- Published
- 2007
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