1. Controlling release from 3D printed medical devices using CLIP and drug-loaded liquid resins.
- Author
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Bloomquist CJ, Mecham MB, Paradzinsky MD, Janusziewicz R, Warner SB, Luft JC, Mecham SJ, Wang AZ, and DeSimone JM
- Subjects
- Chemistry, Pharmaceutical methods, Delayed-Action Preparations, Dexamethasone administration & dosage, Dexamethasone analogs & derivatives, Dexamethasone chemistry, Docetaxel administration & dosage, Docetaxel chemistry, Drug Liberation, Polyesters chemistry, Polyethylene Glycols chemistry, Precision Medicine methods, Rhodamines administration & dosage, Rhodamines chemistry, Time Factors, Drug Carriers chemistry, Drug Delivery Systems, Printing, Three-Dimensional, Technology, Pharmaceutical methods
- Abstract
Mass customization along with the ability to generate designs using medical imaging data makes 3D printing an attractive method for the fabrication of patient-tailored drug and medical devices. Herein we describe the application of Continuous Liquid Interface Production (CLIP) as a method to fabricate biocompatible and drug-loaded devices with controlled release properties, using liquid resins containing active pharmaceutical ingredients (API). In this work, we characterize how the release kinetics of a model small molecule, rhodamine B-base (RhB), are affected by device geometry, network crosslink density, and the polymer composition of polycaprolactone- and poly (ethylene glycol)-based networks. To demonstrate the applicability of using API-loaded liquid resins with CLIP, the UV stability was evaluated for a panel of clinically-relevant small molecule drugs. Finally, select formulations were tested for biocompatibility, degradation and encapsulation of docetaxel (DTXL) and dexamethasone-acetate (DexAc). Formulations were shown to be biocompatible over the course of 175 days of in vitro degradation and the clinically-relevant drugs could be encapsulated and released in a controlled fashion. This study reveals the potential of the CLIP manufacturing platform to serve as a method for the fabrication of patient-specific medical and drug-delivery devices for personalized medicine., (Copyright © 2018. Published by Elsevier B.V.)
- Published
- 2018
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