1. Ozone pretreatment of process waste water generated in course of fluoroquinolone production.
- Author
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Daoud F, Pelzer D, Zuehlke S, Spiteller M, and Kayser O
- Subjects
- Anti-Bacterial Agents chemistry, Chromatography, Liquid, Ciprofloxacin analysis, Fluoroquinolones analysis, Kinetics, Mass Spectrometry, Moxifloxacin, Water analysis, Water Pollutants, Chemical analysis, Fluoroquinolones chemistry, Ozone chemistry, Waste Disposal, Fluid methods, Wastewater chemistry, Water Pollutants, Chemical chemistry
- Abstract
During production of active pharmaceutical ingredients, process waste water is generated at several stages of manufacturing. Whenever possible, the resulting waste water will be processed by conventional waste water treatment plants. Currently, incineration of the process waste water is the method to eliminate compounds with high biological activity. Thus, ozone treatment followed by biological waste water treatment was tested as an alternative method. Two prominent representatives of the large group of fluoroquinolone antibiotics (ciprofloxacin and moxifloxacin) were investigated, focussing on waste water of the bulk production. Elimination of the target compounds and generation of their main transformation products were determined by liquid chromatography - high resolution mass spectrometry (LC-HRMS). The obtained results demonstrated, that the concentration of moxifloxacin and its metabolites can be effectively reduced (>99.7%) prior entering the receiving water. On the contrary, the concentration of ciprofloxacin and its metabolites remained too high for safe discharge, necessitating application of prolonged ozonation for its further degradation. The required ozonation time can be estimated based on the determined kinetics. To assure a low biological activity the ecotoxicity of the ozonated waste water was investigated using three trophic levels. By means of multiple-stage mass spectrometry (MS
n ) experiments several new transformation products of the fluoroquinolones were identified. Thus, previously published proposed structures could be corrected or confirmed., (Copyright © 2017 Elsevier Ltd. All rights reserved.)- Published
- 2017
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