1. 7-Methoxybenzofuran-4-carboxamides as PDE 4 inhibitors: a potential treatment for asthma.
- Author
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Buckley G, Cooper N, Dyke HJ, Galleway F, Gowers L, Gregory JC, Hannah DR, Haughan AF, Hellewell PG, Kendall HJ, Lowe C, Maxey R, Montana JG, Naylor R, Picken CL, Runcie KA, Sabin V, Tuladhar BR, and Warneck JB
- Subjects
- Administration, Oral, Animals, Asthma drug therapy, Benzamides adverse effects, Benzamides chemical synthesis, Benzamides pharmacology, Benzofurans adverse effects, Cyclic Nucleotide Phosphodiesterases, Type 4, Eosinophilia drug therapy, Guinea Pigs, Inhibitory Concentration 50, Phosphodiesterase Inhibitors adverse effects, Phosphodiesterase Inhibitors pharmacology, Pyridines adverse effects, Pyridines chemical synthesis, Pyridines pharmacology, Rolipram adverse effects, Rolipram analogs & derivatives, Rolipram pharmacology, Structure-Activity Relationship, Vomiting chemically induced, 3',5'-Cyclic-AMP Phosphodiesterases antagonists & inhibitors, Benzofurans chemical synthesis, Benzofurans pharmacology, Phosphodiesterase Inhibitors chemical synthesis
- Abstract
The synthesis and pharmacological profile of a novel series of 7-methoxybenzofuran-4-carboxamides is described. Some of these compounds were found to be potent inhibitors of phosphodiesterase type 4 (PDE4).
- Published
- 2000
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